The genomic sequence and analysis of the swine major histocompatibility complex

Genomics
C RenardS Beck

Abstract

We describe the generation and analysis of an integrated sequence map of a 2.4-Mb region of pig chromosome 7, comprising the classical class I region, the extended and classical class II regions, and the class III region of the major histocompatibility complex (MHC), also known as swine leukocyte antigen (SLA) complex. We have identified and manually annotated 151 loci, of which 121 are known genes (predicted to be functional), 18 are pseudogenes, 8 are novel CDS loci, 3 are novel transcripts, and 1 is a putative gene. Nearly all of these loci have homologues in other mammalian genomes but orthologues could be identified with confidence for only 123 genes. The 28 genes (including all the SLA class I genes) for which unambiguous orthology to genes within the human reference MHC could not be established are of particular interest with respect to porcine-specific MHC function and evolution. We have compared the porcine MHC to other mammalian MHC regions and identified the differences between them. In comparison to the human MHC, the main differences include the absence of HLA-A and other class I-like loci, the absence of HLA-DP-like loci, and the separation of the extended and classical class II regions from the rest of the MHC by...Continue Reading

References

Aug 1, 1995·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·F S Kaplan, J P O'Connor
Feb 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M J van EijkH A Lewin
Dec 24, 1998·Nucleic Acids Research·G Benson
May 13, 1999·Immunological Reviews·P ChardonM Vaiman
May 20, 1999·Human Molecular Genetics·R Tazi AhniniF S di Giovine
Sep 29, 1999·Immunogenetics·F W VeltenP Chardon
Apr 26, 2000·Genome Research·S SchwartzW Miller
Sep 28, 2000·Current Opinion in Immunology·J S Logan
Feb 14, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·F Di PalmaS A Ellis
Sep 21, 2002·Immunogenetics·Jennifer G SambrookMelody S Clark
Jan 17, 2003·Genome Research·Scott SchwartzWebb Miller
May 14, 2003·Genome Research·Naoya YuhkiStephen J O'Brien
Jun 26, 2003·Nucleic Acids Research·Ramu ChennaJulie D Thompson
Jul 2, 2003·Molecular Biology and Evolution·Verena EderNicoletta Archidiacono
Aug 9, 2003·Science·Evan E Eichler, David Sankoff
Feb 19, 2004·Cytogenetic and Genome Research·A L GustafsonL C Skow
Apr 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·David J AmorK H Andy Choo
May 5, 2004·Genome Research·Simon C PotterMichele Clamp
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Aug 4, 2004·Genome Research·Riza Daza-VamentaDaniel E Geraghty
Dec 2, 2004·Nature Reviews. Genetics·Roger HortonStephan Beck
Dec 18, 2004·Immunogenetics·James KelleyJohn Trowsdale
Dec 21, 2004·Nucleic Acids Research·Sam Griffiths-JonesAlex Bateman
Dec 21, 2004·Nucleic Acids Research·J L AshurstT Hubbard
Mar 1, 2005·Nature Genetics·Ruta ValentonyteStefan Schreiber

❮ Previous
Next ❯

Citations

Jun 13, 2008·Immunogenetics·James BirchShirley A Ellis
Jul 13, 2007·Genome Biology·Sean J HumphrayJane Rogers
Nov 16, 2007·Nucleic Acids Research·L G WilmingJ L Harrow
Mar 31, 2009·BMC Genomics·Rikke K K VingborgChristian Bendixen
Aug 12, 2010·BMC Genomics·Jianfeng GaoRunlin Z Ma
Jun 4, 2011·Veterinary Research·Marie-Pier LecoursMarcelo Gottschalk
Jun 8, 2011·BMC Proceedings·Rui HuClaire Rogel-Gaillard
May 17, 2013·BMC Genomics·Harry D DawsonChristopher K Tuggle
Apr 17, 2013·Database : the Journal of Biological Databases and Curation·Laurens G WilmingJennifer L Harrow
Mar 14, 2007·Immunogenetics·Laura M TennantPenny P Powell
Apr 24, 2008·Immunogenetics·James BirchShirley A Ellis
Nov 7, 2008·Immunogenetics·Federica BarbisanLeonardo Congiu
Jun 2, 2007·DNA Sequence : the Journal of DNA Sequencing and Mapping·Yang LiuQin Zhang
Feb 16, 2016·Scientific Reports·Justin H J NgMichelle L Baker
Dec 10, 2013·Nucleic Acids Research·Jennifer L HarrowLaurens G Wilming
May 30, 2012·Veterinary Immunology and Immunopathology·Yoshie KametaniAsako Ando
Aug 6, 2010·Journal of Pharmacological and Toxicological Methods·Gerd BodeUNKNOWN Steering Group of the RETHINK Project
Sep 29, 2009·Developmental and Comparative Immunology·Chak-Sum HoDouglas M Smith
Sep 2, 2008·Developmental and Comparative Immunology·Joan K LunneyDouglas M Smith
Mar 26, 2009·Tissue Antigens·C-S HoD M Smith
Nov 26, 2010·Animal Genetics·C L Brinkmeyer-LangfordL C Skow
May 13, 2011·Veterinary Immunology and Immunopathology·Yu GaoClaire Rogel-Gaillard
Dec 17, 2014·PloS One·Weerachai JaratlerdsiriJaime Gongora
Mar 6, 2012·Journal of School Psychology·Gonul SakizAnita Woolfolk Hoy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.