The Genomics of Cannabis and Its Close Relatives

Annual Review of Plant Biology
I KovalchukT F Sharbel

Abstract

Cannabis sativa L. is an important yet controversial plant with a long history of recreational, medicinal, industrial, and agricultural use, and together with its sister genus Humulus, it represents a group of plants with a myriad of academic, agricultural, pharmaceutical, industrial, and social interests. We have performed a meta-analysis of pooled published genomics data, and we present a comprehensive literature review on the evolutionary history of Cannabis and Humulus, including medicinal and industrial applications. We demonstrate that current Cannabis genome assemblies are incomplete, with ∼10% missing, 10-25% unmapped, and 45S and 5S ribosomal DNA clusters as well as centromeres/satellite sequences not represented. These assemblies are also ordered at a low resolution, and their consensus quality clouds the accurate annotation of complete, partial, and pseudogenized gene copies. Considering the importance of genomics in the development of any crop, this analysis underlines the need for a coordinated effort to quantify the genetic and biochemical diversity of this species. Expected final online publication date for the Annual Review of Physical Chemistry, Volume 71 is April 20, 2020. Please see http://www.annualreviews.o...Continue Reading

References

Mar 1, 1991·Science·B Charlesworth
Aug 15, 1970·Experientia·M Kimura, K Okamoto
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C C BurkeR Croteau
Jul 2, 2003·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A PeilW E Weber
May 21, 2005·Annals of Botany·B J M ZonneveldM D Bennett
Jun 3, 2005·Heredity·D CharlesworthG Marais
Aug 23, 2005·Molecular Phylogenetics and Evolution·Nyree J C ZeregaGeorge D Weiblen
Nov 18, 2005·Progress in Lipid Research·Florence BouvierBilal Camara
Feb 21, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Markus KathmannEberhard Schlicker
Apr 7, 2006·Handbook of Experimental Pharmacology·A A Izzo, A A Coutts
Aug 21, 2007·Current Pharmaceutical Biotechnology·Supaart SirikantaramasYukihiro Shoyama
Mar 1, 2008·Journal of Ethnopharmacology·Paola Zanoli, Manuela Zavatti
Jun 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jürg GertschAndreas Zimmer
Sep 9, 2008·Plant Physiology·Guodong WangRichard A Dixon
Nov 28, 2008·Journal of Experimental Botany·Ethan B RussoCheng-Sen Li
Jun 2, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guodong Wang, Richard A Dixon
Apr 30, 2011·Annual Review of Plant Biology·Ray MingSusanne S Renner
May 28, 2011·American Journal of Botany·Charles D BellPamela S Soltis
Oct 22, 2011·Genome Biology·Harm van BakelJonathan E Page
Oct 27, 2011·The Journal of Biological Chemistry·Sharon Anavi-GofferRuth A Ross
Nov 2, 2011·Biochimica Et Biophysica Acta·Seul-Ki ParkMi-Young Lee
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Steve J GagneJonathan E Page
Aug 29, 2013·Therapeutic Advances in Psychopharmacology·Zerrin Atakan
Jun 5, 2014·The New England Journal of Medicine·Nora D VolkowSusan R B Weiss
Nov 25, 2014·Plant & Cell Physiology·Satoshi NatsumeEiichiro Ono
May 23, 2015·Journal of Natural Products·Mohamed M RadwanSamir A Ross
Jun 25, 2015·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Hyehyun OhGi-Sik Min
Jul 3, 2015·Experimental and Therapeutic Medicine·Bokyung SungNam Deuk Kim
Jul 21, 2015·The New Phytologist·George D WeiblenM David Marks
Aug 27, 2015·PloS One·Jason SawlerSean Myles
Sep 4, 2015·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Daniela VergaraNolan C Kane

❮ Previous
Next ❯

Citations

Oct 27, 2020·American Journal of Botany·Jonathan P WengerGeorge D Weiblen
Dec 29, 2020·Journal of Forensic Sciences·Brayan Jonas Mano-SousaJoaquim Maurício Duarte-Almeida
Dec 8, 2020·The New Phytologist·Bhavna HurgobinMathew G Lewsey
Jan 23, 2021·Plants·Adrian S MonthonyAndrew Maxwell P Jones
Jun 3, 2021·International Journal of Molecular Sciences·Mohsen HesamiAndrew Maxwell Phineas Jones
Jun 26, 2021·Journal of Ethnopharmacology·Manica BalantTeresa Garnatje
Jun 9, 2021·Genome Biology and Evolution·Robin van Velzen, M Eric Schranz
Jul 10, 2021·Genome Génome / Conseil National De Recherches Canada·Davoud Torkamaneh, Andrew Maxwell Phineas Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Jørgen G Bramness
Deutsche medizinische Wochenschrift
Barbara Erbe
Drug and Therapeutics Bulletin
Archives of Disease in Childhood
P Robson
© 2021 Meta ULC. All rights reserved