The genotoxic effect of oxcarbazepine on mice blood lymphocytes

Drug and Chemical Toxicology
Huma AkbarIlham Begum

Abstract

This study was conducted to assess the amount of DNA damage caused by Oxcarbazepine (OXC) through single cell gel electrophoresis (SCGE) technique/comet assay. OXC derived from dibenzazepine series is an effective second generation antiepileptic drug (AED) for both children and adults. Side effects like genotoxic effects of AEDs are of prime importance resulting from toxic metabolites, free radicals and reactive oxygen species (ROS). Forty Eight adult male Bagg's albino mice (BALB/c) were randomly classified into eight groups, each comprising of six animals. Two of these groups were control and six were tested groups. Control groups were injected with 1% tween 80 while tested groups were injected with 10, 20, and 40 mg/kg-day OXC for seven days (acute therapy) and 28 days (subchronic therapy) in peritoneal cavity. Blood samples were collected by cardiac puncture and subjected to comet assay for the analysis of DNA damage. Per sample 100 cells were scored and classified according to comet tail length. The results showed that OXC in acute and long term therapies had significantly higher (p < 0.05) genotoxicity in treated groups as compared to control groups. Our study suggests that OXC may cause significant DNA damage in both acu...Continue Reading

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Citations

Sep 25, 2018·International Journal of Occupational and Environmental Health·Muhammad Khisroon Ahmadullah
Mar 28, 2020·Annals of Neurology·Piero PeruccaUNKNOWN EpiPGX and EPIGEN Consortia
Aug 10, 2020·Journal of Occupational and Environmental Medicine·Muhammad KhisroonJaveed Farooqi
Jul 18, 2020·Biological Trace Element Research·Muhammad KhisroonAbid Ullah
Sep 6, 2020·Journal of Occupational and Environmental Medicine·Muhammad KhisroonJaveed Farooqi

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