PMID: 7527904Dec 1, 1994Paper

The genotoxic potential in vitro and in vivo of the allyl benzene etheric oils estragole, basil oil and trans-anethole

Mutation Research
L MüllerT Petr

Abstract

Estragole, trans-anethole and basil oil were tested for their ability to induce DNA repair in rat hepatocytes in vitro and in rat liver in an ex vivo test. There was a marked induction of UDS by estragole and basil oil in vitro (LOEC about 10(-5) mol/l). The basil oil we used contained about 88.2% estragole. It is evident from our results that the induction of UDS with basil oil could be directly related to its main constituent estragole. trans-Anethole was only slightly effective in the in vitro UDS test. The ex vivo UDS test led to clearly elevated DNA repair for estragole and basil oil in rats treated orally with doses up to 2 g/kg body weight. Estragole was not positive in a chromosomal aberration test with V79 cells either via direct treatment, with rat liver S9 mix or with rat hepatocytes as source of metabolism.

References

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Citations

Apr 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A D Marshall, J Caldwell
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J R LazutkaV Dedonyte
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L SmithI G Sipes
Sep 25, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P NewberneR A Ford
Jun 11, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wei DingMugimane G Manjanatha
Feb 3, 2016·The Journal of Parasitology·Claudio B S OliveiraValter F Andrade-Neto
May 26, 2005·Mutation Research·Ivonne M C M RietjensGerrit M Alink
Jan 1, 2008·Toxicology Mechanisms and Methods·Kirk B ArvidsonRonald F Chanderbhan
Jul 6, 2014·Parasite : Journal De La Société Française De Parasitologie·Patrick Akono NtongaPhilippe Grellier
Jan 17, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ludovic Le HégaratValérie Fessard
Nov 2, 2014·Environmental and Molecular Mutagenesis·Wei DingMugimane G Manjanatha
Nov 13, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F BakkaliM Idaomar

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