PMID: 21781790Sep 1, 1997Paper

The genotoxicity of diaveridine and trimethoprim

Environmental Toxicology and Pharmacology
T OnoT Ohta


We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the umu test (Salmonella typhimurium TA1535/pSK1002) and in the reverse mutation tests (S. typhimurium TA100, TA98, TA97, TA102, and Escherichia coli WP2 uvrA/pKM101) in the presence and absence of S9 mix. Diaveridine induced structural chromosome aberrations in cultured Chinese hamster CHL cells in the absence of a metabolic activation system, but not in the presence of a liver S9 fraction. No clastogenic activity in CHL cells was detected for trimethoprim. Bone marrow micronucleus tests in mice and rats conducted on diaveridine by single- and triple-oral dosing protocols were negative. The comet assay revealed that a single oral administration of diaveridine significantly induced DNA damage in liver, kidney, lung, and spleen cells, but not in bone marrow cells. The significant increase in migration values of DNA was reproducible with dose-response relationship. We suggest that the liver detoxifies the compound before i...Continue Reading


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May 1, 1970·Mutation Research·M A Kastenbaum, K O Bowman
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Jan 1, 1980·Mutation Research·T OhtaY Shirasu
Jun 1, 1994·Mutation Research·D GatehouseS Venitt
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill

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