PMID: 21781790Sep 1, 1997Paper

The genotoxicity of diaveridine and trimethoprim

Environmental Toxicology and Pharmacology
T OnoT Ohta

Abstract

We examined the genotoxicity of diaveridine and trimethoprim in the bacterial umu test, the bacterial reverse mutation test, the in vitro chromosome aberration test, the in vivo rodent bone marrow micronucleus test in two species, and the in vivo comet assay in five mouse organs. Both compounds were negative in the umu test (Salmonella typhimurium TA1535/pSK1002) and in the reverse mutation tests (S. typhimurium TA100, TA98, TA97, TA102, and Escherichia coli WP2 uvrA/pKM101) in the presence and absence of S9 mix. Diaveridine induced structural chromosome aberrations in cultured Chinese hamster CHL cells in the absence of a metabolic activation system, but not in the presence of a liver S9 fraction. No clastogenic activity in CHL cells was detected for trimethoprim. Bone marrow micronucleus tests in mice and rats conducted on diaveridine by single- and triple-oral dosing protocols were negative. The comet assay revealed that a single oral administration of diaveridine significantly induced DNA damage in liver, kidney, lung, and spleen cells, but not in bone marrow cells. The significant increase in migration values of DNA was reproducible with dose-response relationship. We suggest that the liver detoxifies the compound before i...Continue Reading

References

Mar 1, 1988·Experimental Cell Research·N P SinghE L Schneider
May 1, 1970·Mutation Research·M A Kastenbaum, K O Bowman
May 1, 1983·Mutation Research·D M Maron, B N Ames
Jan 1, 1980·Mutation Research·T OhtaY Shirasu
Jun 1, 1994·Mutation Research·D GatehouseS Venitt
Feb 1, 1995·Mutation Research·D W FairbairnK L O'Neill

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Citations

Jul 26, 2015·Regulatory Toxicology and Pharmacology : RTP·Xu WangZonghui Yuan
Feb 11, 2015·Journal of Applied Toxicology : JAT·Xu WangZonghui Yuan
Sep 24, 2015·Environmental Toxicology and Pharmacology·Jianzhong WangXingyuan Cao
Jan 18, 2017·Journal of Veterinary Pharmacology and Therapeutics·Y-F LiZ-L Zeng
Jan 29, 2002·Environmental and Molecular Mutagenesis·Tomoko Ono-OgataHideo Yamagata
Jan 18, 2018·Cytotechnology·Devrim Güzel BayülkenKadriye Benkli

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