The Genotype-Tissue Expression (GTEx) project

Nature Genetics
GTEx Consortium


Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants are not correlated with protein-coding changes, suggesting that polymorphisms in regulatory regions probably contribute to many disease phenotypes. Here we describe the Genotype-Tissue Expression (GTEx) project, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.

Associated Clinical Trials


Sep 18, 2007·Nature Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Mar 18, 2008·Nature·Valur EmilssonKari Stefansson
May 9, 2008·PLoS Biology·Eric E SchadtRoger Ulrich
Jul 4, 2008·Trends in Genetics : TIG·Yoav GiladJonathan K Pritchard
Nov 8, 2008·Science·David M AltshulerEric S Lander
May 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lucia A HindorffTeri A Manolio
Sep 4, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Enpeng ZhaoAlan D Attie
Mar 12, 2010·Nature·Joseph K PickrellJonathan K Pritchard
Apr 14, 2010·PLoS Computational Biology·Enrico PetrettoSylvia Richardson
Oct 15, 2010·Nature Biotechnology·Bradley E BernsteinJames A Thomson
Dec 15, 2010·PLoS Genetics·Joseph K PickrellJonathan K Pritchard
Sep 17, 2011·Nature Reviews. Genetics·David W CraigTeri A Manolio
Sep 4, 2012·Nature Genetics·Elin GrundbergMultiple Tissue Human Expression Resource (MuTHER) Consortium
Sep 8, 2012·Nature·ENCODE Project Consortium


Jul 10, 2013·Nature Medicine·Susan Matthews
Apr 20, 2014·Current Cardiology Reports·Gad AbrahamMichael Inouye
Apr 29, 2014·Human Genetics·A Battle, Stephen B Montgomery
Mar 14, 2014·Current Atherosclerosis Reports·Clint L MillerThomas Quertermous
May 3, 2014·The Journal of Clinical Investigation·Larry D MesnerCharles R Farber
Apr 29, 2014·Acta Neuropathologica·Peter T NelsonDavid W Fardo
Jun 5, 2014·BMC Medical Genomics·Marna McKenzieJoseph E Powell
Aug 12, 2014·Trends in Pharmacological Sciences·Avi Ma'ayanYan Kou
Sep 16, 2014·American Journal of Respiratory and Critical Care Medicine·Kehua WuR Stephanie Huang
Aug 26, 2014·Nature Biotechnology·Sheng LiChristopher E Mason
Oct 29, 2014·Nature Neuroscience·Ian MazeEric J Nestler
Nov 20, 2014·Nature Communications·Patrick M A SleimanHakon Hakonarson
Oct 8, 2014·Translational Psychiatry·Y KimPatrick F Sullivan
Aug 1, 2014·PLoS Genetics·Elaine T LimSequencing Initiative Suomi (SISu) Project
Jan 20, 2016·Nature Reviews. Genetics·Ekta KhuranaMark Gerstein
Feb 2, 2016·Nature Genetics·Pratiti BandopadhayayAdam C Resnick
Jan 13, 2016·Human Molecular Genetics·Tune H PersSchizophrenia Working Group of the Psychiatric Genomics Consortium
Dec 3, 2015·Nucleic Acids Research·Yoav D ShaulDavid M Sabatini
Jan 7, 2016·Cardiovascular Research·Nathan R TuckerPatrick T Ellinor
Oct 28, 2015·Nucleic Acids Research·Liyuan GuoJing Wang
Dec 22, 2015·Nucleic Acids Research·Andrew YatesPaul Flicek
Oct 17, 2015·Expert Review of Gastroenterology & Hepatology·Antonella CianferoniAmanda Muir
May 20, 2015·Biomolecules·Alger M FredericksWilliam G Fairbrother
Oct 15, 2014·The Journal of Experimental Medicine·Jean-Laurent CasanovaLuigi D Notarangelo
Feb 25, 2014·FEBS Letters·Matthew G K BeneschDavid N Brindley
May 29, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eric HollanderNaomi A Fineberg
Feb 10, 2016·The Pharmacogenomics Journal·A ChhibberS E Brenner
Aug 6, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deng-Feng ZhangYong-Gang Yao
Apr 15, 2016·EBioMedicine·Theodora KatsilaGeorge P Patrinos

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