PMID: 8953853Nov 1, 1996Paper

The genotypes of hepatitis C virus in patients with chronic hepatitis C virus infection in southern Taiwan

The Kaohsiung Journal of Medical Sciences
M L YuW Y Chang

Abstract

To investigate the genotype distribution of hepatitis C virus (HCV) in southern Taiwan, the sera from 56 patients with chronic HCV infection were studied. Twenty-nine patients were men and 27 were women. Age ranged from 22 to 65 years (mean, 47.3 +/- 11.4). Eighteen of them had chronic persistent hepatitis, 27 had chronic active hepatitis, and 11 had liver cirrhosis. HCV RNA was detected by reverse transcription-nested polymerase chain reaction using primers derived from the 5'-noncoding region. The genotypes of HCV were determined by amplification of the core region with the type-specific primers as described by Okamoto et al.. All sera were positive for HCV RNA. The prevalence rates of genotypes were as follows: 1b/II, 44.6%(25/56); 2a/III, 41.1%(23/56); 2b/IV, 3.6%(2/56); mixed 1b/I + 2a/III, 5.4%(3/56): mixed 1b/II + 2b/IV, 1.8%(1/56) and type unclassified 3.6%(2/56). The distribution of genotypes was not related to the patients' age, sex, and histological changes. Nevertheless, patients having past history of blood transfusion had a significantly higher rate of HCV type 2a/III infection (72.2% versus 34.2%, p < .05, chi-square test). We concluded that both of the HCV genotypes 1 b/II and 2a/III are predominant types in sou...Continue Reading

Citations

Jul 25, 2006·Archives of Dermatological Research·Ayca Cordan YaziciBahar Tasdelen
Oct 23, 2002·International Journal of Dermatology·Xuejun ZhangFuxi Wang
Dec 20, 2005·The Journal of Dermatology·Toshiyuki YamamotoKiyoshi Nishioka
May 9, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·K N KanadaA W Armstrong
Feb 19, 2013·The Journal of Dermatology·Shinichi Imafuku, Juichiro Nakayama
Feb 19, 2013·International Journal of Dermatology·Adriana AbucharFrancisco A Kerdel
Jun 8, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·M AfsharT R Hata
Aug 22, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David R BerkAijaz Ahmed
Aug 13, 2002·Dermatologic Clinics·J Mark Jackson
Aug 2, 2000·The Journal of Dermatology·T Yamamoto, K Nishioka
May 18, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·K ChunT Hata

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