The Genuair® inhaler: a novel, multidose dry powder inhaler

International Journal of Clinical Practice
H Chrystyn, C Niederlaender

Abstract

This article reviews the Genuair(®) inhaler, a novel, multidose, breath-actuated dry powder inhaler. The inhaler design includes visual and acoustic feedback to reassure patients that they have taken their medication correctly, a dose indicator and a lock-out mechanism to prevent the use of an empty inhaler. The inhaler has medium airflow resistance and uses an optimised dispersion system to ensure effective deagglomeration of the inhalation powder. In vitro studies have demonstrated that the inhaler delivers a reproducible aerodynamic aerosol quality and is reliable under various thermal and mechanical stress conditions. Further studies in vitro have demonstrated that the total emitted dose and fine particle dose are both consistent over a range of inhalation flows from 45 to 95 l/min, as well as being independent of inhalation volume (2 l vs. 4 l) and storage conditions. In healthy subjects, delivery of aclidinium bromide 200 μg via the inhaler achieved high lung deposition (approximately 30% of the metered dose). A further study has shown that patients with moderate or severe chronic obstructive pulmonary disease can generate sufficient inspiratory airflow through the inhaler to reliably inhale the full dose and reset the in...Continue Reading

References

Jan 10, 1976·British Medical Journal·I C Paterson, G K Crompton
May 27, 1999·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·K J SmithK F Brown
Sep 2, 1999·International Journal of Pharmaceutics·B J GabrioD J Velasquez
Nov 6, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·L Borgström
Jul 13, 2002·Respiratory Medicine·S P Newman, W W Busse
Oct 24, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M MolimardN Moore
May 14, 2004·Respiratory Medicine·Brian J O'Connor
Dec 18, 2007·Respiratory Medicine·Federico LavoriniGraham K Crompton
May 20, 2009·Respiration; International Review of Thoracic Diseases·S P NewmanG de Miquel
Aug 18, 2009·Pulmonary Pharmacology & Therapeutics·P ChanezE Garcia Gil
Oct 21, 2010·Journal of Clinical Pharmacology·Kenneth C LasseterEsther Garcia Gil
Feb 12, 2011·The European Respiratory Journal·B L LaubeUNKNOWN International Society for Aerosols in Medicine
Apr 27, 2011·Respiratory Research·Paul W JonesEsther Garcia Gil

❮ Previous
Next ❯

Citations

May 9, 2013·Respiratory Research·Donald P Tashkin, Gary T Ferguson
May 8, 2014·Expert Review of Respiratory Medicine·Eric D BatemanDonald Banerji
Sep 15, 2015·Expert Review of Respiratory Medicine·Tony D'UrzoEdward Kerwin
Apr 10, 2013·Expert Opinion on Pharmacotherapy·Mario CazzolaMaria Gabriella Matera
Jun 12, 2013·Expert Opinion on Drug Delivery·Job van der PalenEsther Garcia Gil
Nov 13, 2014·Expert Opinion on Drug Delivery·Priya MuralidharanHeidi M Mansour
Dec 10, 2015·COPD·Francesco BlasiIlaria Baiardini
Apr 17, 2014·Advanced Drug Delivery Reviews·M HoppentochtA H de Boer
Jan 1, 2013·Pulmonary Pharmacology & Therapeutics·Mario CazzolaMaria Gabriella Matera
May 13, 2015·AAPS PharmSciTech·Kai BerkenfeldJason T McConville
Apr 17, 2015·Multidisciplinary Respiratory Medicine·Roberto W Dal Negro
Sep 1, 2016·Respiratory Medicine·Peter HaidlRolf Michael Cloes
Oct 19, 2012·Therapeutic Advances in Respiratory Disease·François Maltais, Julie Milot
Dec 7, 2017·Postgraduate Medicine·Michael DePietroMichael Riebe
May 18, 2019·Therapeutic Advances in Respiratory Disease·Anthony D D'UrzoKenneth R Chapman
Jul 3, 2019·COPD·Helgo MagnussenRoland Greguletz
Oct 11, 2012·Drugs·James E Frampton
Sep 22, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Sohini GhoshM Bradley Drummond
Sep 7, 2016·Multidisciplinary Respiratory Medicine·Roberto W Dal Negro, Massimiliano Povero
Dec 18, 2014·World Journal of Clinical Cases·Clement KleinstreuerEmily Childress
Nov 5, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Tetsuri KondoShigeto Horiuchi
Jun 18, 2021·Expert Review of Respiratory Medicine·Anthony D D'UrzoRobert A Wise
Sep 15, 2021·International Journal of Clinical Practice·Hadeer S HarbMohamed E A Abdelrahim
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Xue JinShui Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.