PMID: 11926126Apr 3, 2002Paper

The genus Bifidobacterium for cancer gene therapy

Current Opinion in Drug Discovery & Development
Minoru FujimoriShun'ichiro Taniguchi

Abstract

A fundamental obstacle in cancer gene therapy is the specific targeting of therapy to solid tumor; as yet, no systemic delivery system exists. Bifidobacterium longum, a strain of domestic bacteria that is non-pathogenic and anaerobic, selectively localized to and proliferated in solid tumors after systemic application. We propose a novel approach to cancer gene therapy in which anaerobic bacteria of the genus B longum are used to achieve tumor-specific gene delivery and enzyme-prodrug therapy.

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