The geographic distribution of the ACE II genotype: a novel finding

Genetical Research
Yolande B SaabA D J Overall

Abstract

Angiotensin converting enzyme (ACE) gene polymorphism insertion (I) or deletion (D) has been widely studied in different populations, and linked to various functional effects and associated with common diseases. The purpose of the present study was to investigate the relationship between the ACE I/D frequency in different populations and geographic location; ACE I/D allele frequency in the Lebanese population and ACE II genotype contribution to the geographic trend were also identified. Five hundred and seventy healthy volunteers were recruited from the Lebanese population. Genomic DNA was extracted from buccal cells, and amplified by polymerase chain reaction; products were then identified by gel electrophoresis. The frequencies of the different ACE I/D genotypes were determined and tested for Hardy-Weinberg equilibrium (HWE). To assess the relationship between ACE I/D frequency and geographic location, and to identify how the Lebanese population contributes to the geographic trend in ACE I/D frequencies, Eurasian population samples and Asians were incorporated in the analyses from the literature. The frequency of the I allele in the Lebanese population was 27% and the corresponding II genotype was at a frequency of 7.37% (in ...Continue Reading

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Citations

Dec 6, 2008·The Journal of Molecular Diagnostics : JMD·Nina KaludercicNazareno Paolocci
Jun 2, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Y B SaabA D J Overall
May 10, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Mostafa Saadat
Apr 15, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Joris R DelangheMarc L De Buyzere
Jul 24, 2020·Journal of Applied Physiology·Kelsey E JoyceSamuel J E Lucas
Aug 19, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Graham ChakafanaKaren Sliwa
Jul 7, 2020·Frontiers in Microbiology·Nora Nganyewo NghochuzieAlfred Amambua-Ngwa
Sep 10, 2020·Tropical Medicine and Infectious Disease·Francesco Di GennaroGiovanni Putoto
Nov 19, 2020·The American Journal of Tropical Medicine and Hygiene·Abdullahi Tunde AborodeFozia Farooq
Dec 19, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Noel PabalanChatchai Muanprasat
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Riadh BadraouiMousa M Alreshidi
Dec 29, 2020·Malaria Journal·Mogahed Ismail Hassan HusseinAnmar Homeida
Mar 14, 2021·Respiratory Medicine·Saeed SamadizadehAlireza Tahamtan
Jul 3, 2021·International Journal of Environmental Research and Public Health·Vito JankoMitja Luštrek

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