The German keratomycosis registry : Initial results of a multicenter survey

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
M RothGerd Geerling

Abstract

Mycotic keratitis is a serious but relatively rare disease. No targeted data collection in Germany existed until the foundation of the German Pilz-Keratitis Register in 2015. The inclusion of retrospective and prospective patients was carried out. diagnosis confirmed by the polymerase chain reaction (PCR), culture, histology or confocal microscopy (IVCM). Collected parameters: date of symptom onset, date and method of diagnosis, risk factors, visual acuity and findings at admission and at follow-up, conservative and surgical treatment. By January 2018, a total of 102 eyes from the years 2000-2017 were reported from 16 centers (64.3% female, mean age 52 years, range 18-95 years). The initial diagnosis was made correctly in only 20.6% of cases. The mean time to correct diagnosis was 31.7 ± 46.9 (0-296) days. The diagnosis was confirmed in cultures in 74.5%, histologically in 30.4%, by PCR in 38.2% and IVCM in 27.4%. Fungal species identified were: 36.7% Fusarium spp., 35.8% Candida spp., 6.4% Aspergillus spp. and 21.1% other. The most important risk factor was the use of contact lenses. The most commonly used antifungal agent was voriconazole (64.7%) followed by amphotericin B (37.2%). Penetrating keratoplasty was performed in 65...Continue Reading

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Citations

Jul 10, 2019·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M RothG Geerling
Mar 4, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Janine LenkSusann Rößler
Aug 22, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·C J FarahL Daas
Sep 9, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Martina C Herwig-CarlKarin U Löffler
Jan 12, 2021·Frontiers in Bioengineering and Biotechnology·Benedikt GöttelKarsten Mäder
Feb 14, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Loïc HamonLoay Daas
Mar 6, 2021·Medical Mycology Case Reports·Alexander M AldejohannDaniel Kampik
Mar 2, 2021·The Lancet Infectious Diseases·Lottie BrownDavid W Denning
Jul 2, 2021·Klinische Monatsblätter für Augenheilkunde·Wolfgang J Behrens-Baumann

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