The germless theory of allergic disease: revisiting the hygiene hypothesis

Nature Reviews. Immunology
M Wills-KarpC L Karp

Abstract

Rising rates of allergic disease accompany the healthier benefits of a contemporary westernized lifestyle, such as low infant mortality. It is likely that these twinned phenomena are causally related. The hygiene hypothesis states that allergy and increased longevity are both consequences of reducing infectious stressors during early childhood for millennia. Mechanistic explanations for the hygiene hypothesis have typically invoked the T-helper-type 1/2 (T(H)1/T(H)2) model. Here, we discuss why we favour a broader 'counter-regulatory' model--one that might also explain the increasing incidence of autoimmune disease in westernized countries.

References

Jun 1, 1991·Acta paediatrica Scandinavica·I AdlerberthL A Hanson
Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Jan 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W W Busse
May 17, 1973·The New England Journal of Medicine·A F WilsonE L Surprenant
Feb 1, 1983·The Journal of Allergy and Clinical Immunology·J W LarrickD Levy
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·F D Martinez
Jun 1, 1995·The Journal of Clinical Investigation·C Zuany-AmorimM Pretolani
Aug 1, 1993·The Journal of Infectious Diseases·D E Griffin, B J Ward
Aug 1, 1993·Infection and Immunity·P F BarnesR L Modlin
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·N R LynchN Alvarez
Feb 1, 1996·American Journal of Respiratory Cell and Molecular Biology·D S RobinsonQ Hamid
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·L BorishS Wenzel
Jun 29, 1996·Lancet·S O ShaheenA Goudiaby
May 1, 1996·Archives of Disease in Childhood·D P StrachanR G Carpenter
Sep 15, 1996·Journal of Neuroscience Research·B CannellaC S Raine
Feb 1, 1997·The Journal of Allergy and Clinical Immunology·H Majamaa, E Isolauri
Jan 1, 1997·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·T Nicolai, E von Mutius
Aug 9, 1997·Lancet·J S AlmA Scheynius
May 9, 1998·The Journal of Allergy and Clinical Immunology·P M MatricardiF Rosmini
Jul 17, 1998·The American Journal of Pathology·F AutschbachS C Meuer
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·K HobbsL Borish
Dec 16, 1998·Current Opinion in Pediatrics·S E Crater, T A Platts-Mills
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R J Buckley
Feb 13, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S L PrescottP G Holt
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S A Lewis, J R Britton
Feb 25, 1999·Epidemiology and Infection·I AdlerberthA E Wold
Apr 8, 1999·Thorax·I S Farooqi, J M Hopkin
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B BjörksténM Mikelsaar
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K WickensR Beasley
May 29, 1999·Environmental Health Perspectives·P A EgglestonJ J Jaakkola
Sep 3, 1999·Clinical and Diagnostic Laboratory Immunology·T AzimM J Albert
Jan 27, 2000·JAMA : the Journal of the American Medical Association·M PaunioH Peltola
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M KilpeläinenM Koskenvuo

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Citations

Feb 20, 2007·Inflammatory Bowel Diseases·Giovanni LatellaRenzo Caprilli
Sep 4, 2012·Seminars in Immunopathology·Taylor FeehleyCathryn R Nagler
Apr 12, 2007·Wiener medizinische Wochenschrift·Sandra ScheiblhoferJosef Thalhamer
Oct 27, 2010·European Journal of Epidemiology·Sarah J HepworthPatricia A McKinney
Sep 24, 2008·Journal of Clinical Immunology·Elizabeth Wohlfert, Yasmine Belkaid
May 17, 2007·Current Allergy and Asthma Reports·M Luisa Baeza, José Manuel Zubeldia
Aug 7, 2008·Current Allergy and Asthma Reports·William Harnett, Margaret M Harnett
May 18, 2004·Clinical Reviews in Allergy & Immunology·Mor Ndiaye, Jean Bousquet
Apr 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·M V R Reddy
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Dugald ChisholmAnthony A Horner
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Donata Vercelli
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Jared BoasenAnthony A Horner
May 26, 2004·Leukemia Research·Nikolaus BeckerAlexandra Nieters
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Petra Verdino, Walter Keller
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Karin DeinhoferSusanne Spitzauer
Aug 17, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·P J CooperG E Griffin
Oct 19, 2002·Molecular Aspects of Medicine·Sylvia M Miescher, Monique Vogel
Jun 18, 2003·Current Opinion in Pharmacology·A Barry Kay
Sep 24, 2009·The British Journal of Nutrition·Kei SonoyamaTetsuji Yanagihara
Jun 20, 2008·Expert Reviews in Molecular Medicine·William Harnett, Margaret M Harnett
Jun 1, 2012·Journal of Developmental Origins of Health and Disease·P M HansbroJ C Horvat
Mar 22, 2002·Nature Reviews. Immunology·C B Wilson, E K Marcuse
Dec 25, 2009·Mucosal Immunology·M Wills-KarpC L Karp
May 28, 2010·Mucosal Immunology·C M Lloyd, J R Murdoch
Nov 29, 2001·Nature Immunology·M Wills-Karp
Dec 8, 2004·Nature Medicine·Charlotte Schubert
Feb 10, 2006·Nature Reviews. Cancer·Mel Greaves
May 15, 2004·Nature Reviews. Genetics·Marsha Wills-Karp, Susan L Ewart
Jun 3, 2004·Nature Reviews. Immunology·Andrew J Macpherson, Nicola L Harris
Mar 19, 2005·Nature Reviews. Immunology·C M Hawrylowicz, A O'Garra
Oct 7, 2006·Nature Reviews. Immunology·Sarkis K Mazmanian, Dennis L Kasper

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