Abstract
The Geropathology Grading Platform (GGP) that is being developed by the Geropathology Research Network provides a grading system that allows investigators to assess biological aging in mice by measuring the pathological status of a wide range of tissues in a standardized scoring system. The GGP is a grading system that generates a numerical score for the total lesions in each tissue, which when averaged over the mice in the cohort provides a composite lesion score (CLS) for each tissue and mouse. In this study, we tested ability of the GGP to predict accelerated aging in mice null for Cu/Zn-superoxide dismutase (Sod1KO mice), which have been shown to have reduced lifespan and healthspan. Using the GGP, we evaluated the pathological status of 11 tissues from male and female wild-type (WT) and Sod1KO mice at 9 to 10 months of age. The whole animal CLS was 2- to 3.5-fold higher for both male and female Sod1KO mice compared to WT mice. The tissues most affected in the Sod1KO mice were the liver, lung, and kidney. These data demonstrate that the GGP is able to predict the accelerated aging phenotype observed in the Sod1KO mice and correlates with the changes in healthspan that have been reported for Sod1KO mice. Thus, the GGP is a n...Continue Reading
References
Nov 9, 2004·Oncogene·Sailaja ElchuriTing-Ting Huang
Aug 2, 2005·Hearing Research·Elizabeth M KeithleyKenneth R Johnson
May 24, 2006·Free Radical Biology & Medicine·Florian L MullerHolly Van Remmen
Mar 14, 2007·Free Radical Biology & Medicine·Eva M OlofssonAnders Behndig
Dec 31, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Youngmok C JangHolly Van Remmen
Mar 31, 2010·Molecular and Cellular Biochemistry·Yoshihito IuchiJunichi Fujii
Jan 18, 2013·Nature·Simon C JohnsonMatt Kaeberlein
Mar 6, 2013·Free Radical Biology & Medicine·Yiqiang ZhangHolly Van Remmen
Sep 26, 2013·The Journal of Clinical Investigation·Arlan Richardson
Dec 8, 2014·Experimental Gerontology·Arlan RichardsonSalvatore Oddo
Aug 6, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Warren LadigesDenny Liggitt
Oct 6, 2016·Aging·Kathleen E FischerSteven N Austad
Nov 16, 2016·Redox Biology·Yiqiang ZhangArlan Richardson
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Warren LadigesDenny Liggitt
Apr 15, 2017·GeroScience·Sathyaseelan S DeepaArlan Richardson
May 19, 2017·Pathobiology of Aging & Age Related Diseases·Warren Ladiges
Citations
Aug 8, 2018·GeroScience·Matt Kaeberlein
May 1, 2019·GeroScience·Anna CsiszarZoltan Ungvari
Sep 10, 2019·Pathobiology of Aging & Age Related Diseases·Elizabeth FernandezAdam B Salmon
Sep 5, 2020·Aging Cell·Shylesh BhaskaranHolly Van Remmen
Mar 16, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Anna CsiszarZoltan Ungvari
Oct 24, 2019·GeroScience·Sreemathi LoganSathyaseelan S Deepa
Mar 18, 2021·Cell Reports·Jennifer E KayBevin P Engelward
Oct 5, 2021·GeroScience·Holly Van RemmenArlan Richardson