PMID: 9437229Jan 23, 1998Paper

The GH, prolactin, ACTH and cortisol responses to Hexarelin, a synthetic hexapeptide, undergo different age-related variations

European Journal of Endocrinology
E ArvatE Ghigo

Abstract

Hexarelin (HEX) is a synthetic growth hormone-releasing peptide (GHRP) which acts on specific receptors at both the pituitary and the hypothalamic level to stimulate GH release in an age-dependent manner. Like other GHRPs, HEX possesses also prolactin (PRL) and ACTH/cortisol-releasing activity. similar to that of human corticotropin-releasing hormone (hCRH). The mechanisms underlying the stimulatory effect of GHRPs on lactotrope and corticotrope secretion are even less clear and the influence of age on these endocrine activities of GHRPs is unknown. To clarify this point we studied the GH, PRL, ACTH and cortisol responses to the maximal effective dose of HEX (2.0 micrograms/kg i.v.) in: 12 prepubertal children (Pre-C, 8 male, 4 female, age 5.8-12.1 years); 12 pubertal normal short children (Pub-C, 5 male, 7 female, age 9.7-15.5 years, pubertal stage II-IV); 20 normal young adults (Young, 6 males, 14 females, age 23-32 years); and in 16 normal elderly people (Elderly, 5 male, 11 female, age 66-81 years). The GH response to HEX was clear in Pre-C (0-120 min area under curve, mean +/- S.E.M. 769.5 +/- 122.2 micrograms*min/l) but strikingly increased (P < 0.001) in Pub-C (1960.2 +/- 283.5 micrograms*min/l). The HEX-induced GH rise ...Continue Reading

Citations

Jun 28, 2003·Neurobiology of Aging·Johannes D Veldhuis
Jul 1, 1997·Baillière's Clinical Endocrinology and Metabolism·F C MartinP H Sonksen
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·V L Fuh, M A Bach
Sep 11, 2004·Psychoneuroendocrinology·Christian OtteDavid C Mohr
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E GhigoF Camanni
Nov 8, 2011·Peptides·Alessandra BaragliEzio Ghigo
Nov 7, 2013·The Journal of Endocrinology·Manuel D GaheteRaúl M Luque
Apr 14, 2006·Journal of Pharmacological Sciences·Hiroshi HosodaKenji Kangawa
Jun 8, 2004·Endocrine Reviews·Aart J van der LelyEzio Ghigo
Dec 12, 2001·The Journal of Clinical Endocrinology and Metabolism·S M AndersonJ D Veldhuis
May 13, 2003·Journal of Endocrinological Investigation·M R A MartinsA M J Lengyel

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