The Ginkgo biloba extract, EGb 761, fails to reduce brain infarct size in rats after transient, middle cerebral artery occlusion in conditions of unprevented, ischemia-induced fever

Phytotherapy Research : PTR
Keli Carina Miltus de LimaHumberto Milani

Abstract

There is much biochemical evidence, but very few studies in animal models of stroke in vivo, to suggest that Ginkgo biloba (EGb 761) may offer neuroprotection against regional, ischemic brain damage; additional investigations are needed to ensure future clinical trials. This study reports the effects of EGb 761 given acutely or chronically before ischemia. Rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h and the brain infarct size was assessed 24 h later. Dipyrone (100 mg/kg, i.p.) was injected 30 min before ischemia, and 2.5 and 5.5 h after ischemia, to reduce ischemia-induced fever. EGb 761 (Tebonin) was given acutely (200 mg/kg, p.o., 60 min before ischemia) or chronically (100 mg/kg, p.o., once daily, for 14 days before ischemia). Acute or chronic treatment with EGb 761, either alone or in combination with dipyrone, did not reduce the infarct size compared with saline alone (p > 0.05). Dipyrone failed to prevent ischemia-induced fever during the intra-ischemic period (p > 0.05 vs saline; p < 0.001 vs sham). In the reperfusion phase, dipyrone reduced fever to normothermic levels in the group treated acutely with EGb 761 (p < 0.01 vs saline, p > 0.05 vs sham) but not after chronic EGb 761 (p < 0.01 vs sh...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 1, 1995·Stroke; a Journal of Cerebral Circulation·S E Smith, B S Meldrum
Feb 24, 1998·Stroke; a Journal of Cerebral Circulation·M D Ginsberg, R Busto
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·W M ClarkM J Cipolla
Aug 3, 2002·Stroke; a Journal of Cerebral Circulation·David J GladstoneUNKNOWN Heart and Stroke Foundation of Ontario Centre of Excellence in Stroke Recovery
Jul 10, 2003·Lancet Neurology·Tom Skyhøj OlsenLars Peter Kammersgaard
Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C L R SchilichtingH Milani
May 20, 2005·The Journal of Pharmacy and Pharmacology·Shyam S ChatterjeeEgon Koch

❮ Previous
Next ❯

Citations

Jul 10, 2014·The American Journal of Chinese Medicine·Bo YinBenyan Luo
Nov 26, 2015·Integrative Medicine Insights·Kevin M Nash, Zahoor A Shah
Aug 16, 2017·The Journal of Pharmacy and Pharmacology·Shuya WangZhidong Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.