The GINS complex: structure and function

Sub-cellular Biochemistry
Katsuhiko Kamada

Abstract

Eukaryotic chromosomal DNA replication is controlled by a highly ordered series of steps involving multiple proteins at replication origins. The eukaryotic GINS complex is essential for the establishment of DNA replication forks and replisome progression. GINS is one of the core components of the eukaryotic replicative helicase, the CMG (Cdc45-MCM-GINS) complex, which unwinds duplex DNA ahead of the moving replication fork. Eukaryotic GINS also links with other key proteins at the fork to maintain an active replisome progression complex. Archaeal GINS homologues play a central role in chromosome replication by associating with other replisome components. This chapter focuses on the molecular events related with DNA replication initiation, and summarizes our current understanding of the function, structure and evolution of the GINS complex in eukaryotes and archaea.

Citations

Nov 26, 2014·Annual Review of Genetics·Lori M Kelman, Zvi Kelman
Dec 17, 2015·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Le Ou-YangXiao-Fei Zhang
Mar 19, 2014·Molecular Microbiology·Ewa GrabowskaIwona J Fijalkowska
May 12, 2020·Cancer Science·Han-Yun HsiehNobuyuki Takakura
Feb 16, 2013·Chromosoma·Silvia Onesti, Stuart A MacNeill
Dec 2, 2020·Open Biology·Patricia Pérez-ArnaizThorsten Allers

Related Concepts

CDC45L protein, human
Archaea
DNA Replication
Structure-Activity Relationship
Cell Cycle Proteins
Evolution, Molecular
DNA, Archaeal
Archaeal Proteins
Multiprotein Complexes
Minichromosome Maintenance Proteins

Related Feeds

Archaeogenetics

Recent advances in genomic sequencing has led to the discovery of new strains of Archaea and shed light on their evolutionary history. Discover the latest research on Archaeogenetics here.