The Glasgow Prognostic Score (GPS) predicts toxicity and efficacy in platinum-based treated patients with metastatic lung cancer

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Ioannis GioulbasanisVassilios Georgoulias

Abstract

Lung cancer is the most common cause of cancer death. A cumulative prognostic score based on C-reactive protein and albumin, termed the Glasgow Prognostic Score (GPS), indicates the presence of systemic inflammatory response. GPS has been proposed as a powerful prognostic tool for patients with various types of malignant tumors, including lung cancer. The aim of this study was to assess the predictive value of baseline GPS in terms of toxicity and response in lung cancer patients treated with platinum-based chemotherapy. Patients referred to our institution for consideration of first-line platinum-based treatment were eligible. Demographics and disease-related characteristics were recorded. Toxicity was graded according to NCI CTCAE version 3.0 throughout first-line therapy. GPS was calculated before the onset of treatment and was related to the development of toxicity. Response to first-line therapy and survival data were also collected. Totally, 96 lung cancer patients were accrued. GPS was associated with increased mucositis p=0.004), neurotoxicity (p=0.038), neutropenia (p=0.02), dose reductions or/ and need for granulocyte colony-stimulating factor (G-CSF) support (p=0.005), toxicity-related termination of treatment (p=0.0...Continue Reading

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Citations

Apr 15, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Claribel P SimmonsBarry J Laird
Dec 31, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Takuro MiyazakiTakeshi Nagayasu
Nov 3, 2012·American Journal of Surgery·Mitsuru IshizukaKeiichi Kubota
Oct 28, 2017·The International Journal of Biological Markers·Jing JinWeimin Li
Dec 2, 2015·The European Respiratory Journal·Jordi RemonJean-Paul Sculier
Jan 25, 2014·Journal of Pharmacy & Bioallied Sciences·Thierry F Vandamme
Jun 8, 2017·Molecular and Clinical Oncology·Carsten NiederEllinor Haukland
Jan 30, 2021·Systematic Reviews·Anne Winther-LarsenBirgitte Sandfeld-Paulsen

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