The Glaucoma Intensive Treatment Study (GITS), a randomized clinical trial: design, methodology and baseline data

Acta Ophthalmologica
Boel BengtssonChristina Lindén

Abstract

The primary objective of the ongoing Glaucoma Intensive Treatment Study (GITS) is to evaluate the effectiveness of immediate intensive treatment in comparison with the commonly recommended stepped regimen on the predicted visual field. The two treatment arms are also being compared regarding quality of life (QoL), intraocular pressure (IOP) reduction, frequency of reported side-effects, adverse events and adherence to prescribed treatment. A randomized, two-centre, prospective open-labelled treatment trial for open-angle glaucoma. Individuals aged 40-78 years with previously untreated and newly diagnosed glaucoma with early to moderate visual field loss were eligible. Patients were randomized to initial treatment either using drug monotherapy in accordance with common glaucoma guidelines or using a more intensive approach including eyedrops containing drugs from three different classes combined with 360° laser trabeculoplasty. The patients are to be followed for 5 years at visits including standard automated perimetry, optical coherence tomography (OPT) and tonometry. Change of treatment is allowed and decided upon jointly with the patient as in conventional glaucoma management. The estimated predicted preserved visual field an...Continue Reading

References

Oct 1, 1991·Acta Ophthalmologica·M DavangerS Blika
Dec 1, 1988·The British Journal of Ophthalmology·J L Jay, S B Murray
Jan 1, 1996·Archives of Ophthalmology·A Heijl, B Bengtsson
Dec 1, 1995·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A I McNaughtR A Hitchings
Jun 1, 1997·Archives of Ophthalmology·P GutierrezC M Mangione
Nov 21, 1997·Archives of Ophthalmology·R K ParrishA Montenegro-Piniella
Nov 26, 1999·Ophthalmology·M C LeskeB Bengtsson
Oct 9, 2002·Archives of Ophthalmology·Anders HeijlUNKNOWN Early Manifest Glaucoma Trial Group
Dec 18, 2002·Acta Ophthalmologica Scandinavica·Kirsti GrødumBo Bengtsson
Jan 14, 2003·Archives of Ophthalmology·M Cristina LeskeUNKNOWN Early Manifest Glaucoma Trial Group
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Mar 19, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kirsti GrødumBo Bengtsson
Mar 5, 2005·Ophthalmology·Kirsti GrødumBo Bengtsson
Jul 16, 2005·Ophthalmology·Leslie G HymanUNKNOWN Early Manifest Glaucoma Trial Group
Nov 8, 2007·Acta Ophthalmologica Scandinavica·Siv Aström, Christina Lindén
Nov 13, 2007·Ophthalmology·Roberta McKean-CowdinUNKNOWN Los Angeles Latino Eye Study Group
Dec 15, 2007·American Journal of Ophthalmology·Boel Bengtsson, Anders Heijl
Mar 8, 2008·BMC Ophthalmology·Georgios LabirisEvangelia Tsironi
Nov 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Stuart K GardinerChris A Johnson
May 12, 2009·American Journal of Ophthalmology·Arsaell ArnarssonFridbert Jonasson
Dec 17, 2009·Archives of Ophthalmology·Boel BengtssonAnders Heijl
Jan 22, 2010·Investigative Ophthalmology & Visual Science·Manjula MarellaEcosse L Lamoureux
Jan 25, 2011·American Journal of Ophthalmology·Theodore KrupinUNKNOWN Low-Pressure Glaucoma Study Group
Sep 10, 2011·Eye·C WesselinkN M Jansonius
Sep 19, 2012·Ophthalmology·David F Garway-HeathUNKNOWN United Kingdom Glaucoma Treatment Study Investigators
Oct 17, 2012·Acta Ophthalmologica·Anders HeijlBoel Bengtsson
Jan 4, 2013·Acta Ophthalmologica. Supplement·Anders HeijlUNKNOWN Swedish Ophthalmological Society
Sep 14, 2013·Investigative Ophthalmology & Visual Science·Susan R BryanEmmanuel M E H Lesaffre
Nov 28, 2013·Investigative Ophthalmology & Visual Science·Luke J SaundersDavid P Crabb
Nov 8, 2014·Investigative Ophthalmology & Visual Science·Andrew ChenJoseph Caprioli
Jan 15, 2016·Journal of Glaucoma·Kazuyuki HirookaAkitaka Tsujikawa
May 5, 2017·Journal of Ophthalmology·Lee JonesDavid P Crabb

❮ Previous
Next ❯

Citations

Oct 31, 2020·Acta Ophthalmologica·Erika RasmusonGauti Jóhannesson
Sep 6, 2020·American Journal of Ophthalmology·Rouxi ZhouWei Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.