The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017.

The Lancet Oncology
GBD 2017 Childhood Cancer Collaborators

Abstract

Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). Using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0-19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final p...Continue Reading

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Dec 14, 2019·Cancer Metastasis Reviews·Patricia KattnerKlaus-Michael Debatin
Mar 10, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Zbigniew P KortylewiczJanina Baranowska-Kortylewicz
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Software Mentioned

GBD Results
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GBD Results Tool
GBD Compare Tool
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