The global development and clinical efficacy of sublingual tablet immunotherapy for allergic diseases

Allergology International : Official Journal of the Japanese Society of Allergology
Hendrik Nolte, Jennifer Maloney

Abstract

Allergy immunotherapy (AIT) is a treatment option for respiratory allergy that is complementary to pharmacotherapy, with a distinct mechanism of action. Alternative methods to subcutaneous administration of AIT that enable patients to safely self-administer AIT is considered an unmet clinical need. The sublingual immunotherapy tablet (SLIT-tablet) is an orally disintegrating pharmaceutical formulation (oral lyophilisate) containing standardized allergens. SLIT-tablets have been developed for sublingual immunotherapy (SLIT) of cedar-pollen, grass-pollen, ragweed-pollen, tree-pollen, and house dust mite allergies. It is a once-daily tablet treatment to be self-administered after the first dose has been provided under the supervision of a physician with experience in the diagnosis and treatment of allergic diseases. Once the first dose is adequately tolerated, subsequent doses may be self-administered. SLIT-tablets have proven efficacy for allergic rhinitis (AR) with and without conjunctivitis (C) and allergic asthma (AA) in adults, children, and poly-sensitized allergic patients. Meta-analyses indicate that SLIT-tablets have superior or similar efficacy compared with anti-allergic pharmacotherapies for seasonal AR and superior ef...Continue Reading

Citations

Aug 30, 2019·Current Opinion in Allergy and Clinical Immunology·Leonard Bielory, Dovid Schoenberg
May 22, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Montserrat Alvaro-LozanoMarta Vazquez-Ortiz
Jul 17, 2019·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Weibin DuKensuke Natsui
May 27, 2020·Allergologia et immunopathologia·Karsten Münstedt, Heidrun Männle
Jan 7, 2021·Allergy and Asthma Proceedings·Yuriy BisyukLawrence M DuBuske
Jan 21, 2021·Expert Review of Clinical Immunology·Giorgio Ciprandi, Maria Angela Tosca
Sep 10, 2020·Allergology International : Official Journal of the Japanese Society of Allergology·Umut C KucuksezerCezmi A Akdis
Oct 24, 2019·Current Pediatric Reviews·Carlo CaffarelliGiampaolo Ricci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.