The Global Initiative for Asthma 2019 recommendation for mild asthma - A critique.

South African Family Practice : Official Journal of the South African Academy of Family Practice/Primary Care
Elvis M Irusen

Abstract

Recognising that mild asthmatics are at risk of exacerbations and mortality, the Global Initiative for Asthma (GINA) issued an updated strategy in 2019. This was premised on two studies culminating in their recommendation that mild asthma should be treated by using a combination of a rapid and long-acting beta 2 agonist and an inhaled corticosteroid (ICS) administered as required. Their rationale is, however, debatable, as the studies actually showed that regular daily ICS administration was more effective for a number of asthma control endpoints. A patient-driven treatment strategy is also questionable, as there are a number of concerns about behaviour of patients suffering from asthma and perception of airway narrowing that should trigger medication intake but in fact does not do so. These deficiencies also influence a similar maintenance and reliever treatment (MART) approach that would be suboptimal. Intermittent ICS regimens are also inferior when compared to regular treatment. Not all asthmatics respond to the same dose of ICS. The best way to manage asthma is by adopting a step-up ICS approach, to encompass varying disease severity, with a long-acting beta agonist taken on a daily basis, ideally in a single combination i...Continue Reading

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Citations

Apr 30, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Corrado PelaiaNunzio Crimi
Jun 10, 2020·Allergy·Davinder KaurChristopher E Brightling
Oct 1, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Trine H KaasBo L Chawes

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