The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa

Environmental Microbiology
Juan Francisco LinaresJ L Martínez

Abstract

The capacity of a bacterial pathogen to produce a disease in a treated host depends on the former's virulence and resistance to antibiotics. Several scattered pieces of evidence suggest that these two characteristics can be influenced by bacterial metabolism. This potential relationship is particularly important upon infection of a host, a situation that demands bacteria adapt their physiology to their new environment, making use of newly available nutrients. To explore the potential cross-talk between bacterial metabolism, antibiotic resistance and virulence, a Pseudomonas aeruginosa model was used. This species is an important opportunistic pathogen intrinsically resistant to many antibiotics. The role of Crc, a global regulator that controls the metabolism of carbon sources and catabolite repression in Pseudomonas, was analysed to determine its contribution to the intrinsic antibiotic resistance and virulence of P. aeruginosa. Using proteomic analyses, high-throughput metabolic tests and functional assays, the present work shows the virulence and antibiotic resistance of this pathogen to be linked to its physiology, and to be under the control (directly or indirectly) of Crc. A P. aeruginosa strain lacking the Crc regulator ...Continue Reading

References

Feb 1, 1992·Journal of Leukocyte Biology·C D McClure, N L Schiller
Jan 1, 1988·Clinical Microbiology Reviews·K Bush
Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
Jan 1, 1993·Journal of Computer Assisted Tomography·S W Atlas
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·X Z LiK Poole
Jul 1, 1996·Research in Microbiology·D N CollierP V Phibbs
Jun 1, 1997·Journal of Bacteriology·A M AlbusB H Iglewski
Jan 30, 1999·Antimicrobial Agents and Chemotherapy·T MineT Tsuchiya
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·M H Rashid, A Kornberg
Oct 10, 2001·Journal of Bacteriology·L A Gallagher, C Manoil
May 11, 2002·Journal of Bacteriology·Pierre CossonThilo Köhler
Aug 16, 2002·Current Opinion in Biotechnology·Eliora Z Ron, Eugene Rosenberg
Oct 31, 2002·The Journal of Antimicrobial Chemotherapy·Patricia SánchezJosé L Martínez
Apr 16, 2003·Molecular Microbiology·Thomas WeilbacherTony Romeo
Jun 28, 2003·FEMS Microbiology Reviews·Simon C AndrewsFrancisco Rodríguez-Quiñones
Jul 26, 2003·The EMBO Journal·Morten HentzerMichael Givskov
Jan 24, 2004·The Journal of Antimicrobial Chemotherapy·Ana AlonsoJose L Martinez
Feb 24, 2004·Infection and Immunity·Arne RietschJohn J Mekalanos
Jun 9, 2004·Microbiology·Bart GhyselsPierre Cornelis
Oct 7, 2004·Journal of Bacteriology·Alexander J CartersonMichael J Schurr

❮ Previous
Next ❯

Citations

May 25, 2011·Applied Microbiology and Biotechnology·Elisabeth Sonnleitner, Dieter Haas
Nov 13, 2012·Nucleic Acids Research·Deepak BalasubramanianKalai Mathee
Jun 29, 2011·Future Microbiology·José L MartínezJordi Vila
Jun 20, 2014·PLoS Genetics·Elisabeth Sonnleitner, Udo Bläsi
Mar 8, 2012·Future Medicinal Chemistry·José L Martínez
Apr 9, 2013·Applied Microbiology and Biotechnology·Gwynneth Felicity MatcherRosemary Ann Dorrington
Sep 4, 2014·The Journal of Antimicrobial Chemotherapy·Alicia FajardoJose L Martinez
Oct 10, 2013·Briefings in Bioinformatics·Nadine Castelhano SantosAnália Lourenço
Nov 28, 2012·Trends in Microbiology·Jacob R Chambers, Karin Sauer
Jun 15, 2011·Trends in Microbiology·Elena B M BreidensteinRobert E W Hancock
Oct 8, 2013·Microbial Ecology·Lawrence R MulcahyKim Lewis
Aug 4, 2012·Environmental Microbiology·José L Martínez
Nov 22, 2011·Molecular Microbiology·S Marzi, P Romby
Dec 30, 2015·Environmental Microbiology Reports·Sebastian FischerBurkhard Tümmler
May 23, 2014·Drug Discovery Today. Technologies·Jose L Martinez
Jun 8, 2011·FEMS Microbiology Reviews·José L Martínez, Fernando Rojo
Feb 18, 2012·RNA Biology·Elisabeth SonnleitnerUdo Bläsi
Nov 27, 2010·Seminars in Cell & Developmental Biology·Michael Steinert
Dec 8, 2010·Seminars in Cell & Developmental Biology·Wanessa C LimaPierre Cosson
Feb 6, 2014·Biomolecular NMR Assignments·Rakhi SharmaMandar V Deshmukh
Apr 24, 2016·Research in Microbiology·José A Reales-CalderonJosé L Martínez
Jun 16, 2016·Future Medicinal Chemistry·Fernando CoronaJosé L Martínez
Apr 7, 2017·Molecular Plant-microbe Interactions : MPMI·Suma ChakravarthyMelanie J Filiatrault
Jan 25, 2017·Scientific Reports·Thomas ClamensOlivier Lesouhaitier
May 1, 2018·Environmental Microbiology·Dione L Sánchez-HeviaFernando Rojo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.