The glomerular filtration rate in unrestrained rabbits determined by means of an implanted telemetrical device

Acta Physiologica Scandinavica
S Vadstrup, J Bojsen

Abstract

An implanted radio-telemetrical device, which consists of a Geiger-Müller detector, a high voltage supply and a FM transmitter, incapsulated in araldite (weight 130 g) was used to measure the body disappearance rate of 125I-iothalamate following a single i.v. bolus in unrestrained and undisturbed rabbits. The disappearance curve is practically monoexponential from 10 to 60 minutes after administration of the indicator and the disappearance rate constant (Ke) is closely correlated to the "final slope" of the plasma disappearance curve of 125I-iothalamate (kp) r=0.99). A linear correlation was also found between Ke and GFR measured simultaneously by constant infusion clearance technique, using an indicator not detected by the Geiger-Müller detector (51Cr-EDTA) (r=0.98). The ratios between the renal clearances of 125I-iothalamate, 51Cr-EDTA and inulin were determined by constant infusion clearance technique in a separate series of experiments since no data were available in the present literature. The results show that GFR can be determined by means of the telemetrical method and in a series of experiments in undisturbed rabbits GFR was found to be on average 4.7 ml . min-1 . kg-1 (expressed as inulin clearance). Using the same te...Continue Reading

References

Feb 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·N RossingP L Frederiksen
Apr 1, 1976·Acta Endocrinologica·S Vadstrup, J Bojsen
Apr 1, 1976·Acta Endocrinologica·S Vadstrup, J Bojsen
Sep 1, 1976·Journal of Applied Physiology·J Bojsen, S Vadstrup
Nov 1, 1972·The International Journal of Applied Radiation and Isotopes·J Bojsen, K Wallevik
Feb 1, 1970·The American Journal of Physiology·M D Blaufox, A Cohen
May 1, 1971·Journal of Applied Physiology·J A GagnonL U Mailloux
Oct 1, 1969·Radiology·R J Riep, W B Nelp
Oct 1, 1980·Scandinavian Journal of Clinical and Laboratory Investigation·J Brøchner-Mortensen
Jan 1, 1952·Acta Medica Scandinavica. Supplementum·E BOJESEN

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Citations

Jun 23, 2006·Clinical and Experimental Nephrology·Yohkazu MatsushimaMasashi Imai
Nov 22, 2007·Basic & Clinical Pharmacology & Toxicology·Magdalena F P C van JaarsveldJan B du Plessis

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