The glomerular mesangium. II. Studies of macromolecular uptake in nephrotoxic nephritis in rats

The Journal of Clinical Investigation
S M MauerA F Michael

Abstract

These studies were designed to explore the effects of nephrotoxic serum (NTS) in rats on the uptake and processing by the glomerular mesangium of intravenously administered protein macromolecules (radiolabeled aggregated human IgG, [125I]AHIgG). Measurements of [125I]AHIgG levels in preparations of isolated glomeruli correlated well with qualitative estimates of glomerular IgG deposition seen by immunofluorescent microscopy. Rats given 2 ml NTS received 25 mg/100 g body wt [125I]AHIgG 48 h later and were sacrificed at varying time intervals thereafter. NTS-treated animals demonstrated a marked increase in glomerular uptake of [125I]AHIgG as compared with concurrent controls but a normal ability to clear [125I]AHIgG from the mesangium over 72 hr. Animals given 1.0, 0.5, and 0.25 ml NTS had neither proteinuria nor significant light microscopic changes, yet had increased uptake of [125I]AHIgG of 4.4, 3.0, and 2.1 times control values, respectively at 8 h after the infusion of aggregates. Rats given 1 ml NTS and 12.5, 6.25, and 3.125 mg [125I]AHIgG/100 g body wt had increased glomerular uptake at 8 h, but there was, within both NTS and control groups, a disproportionate decrease in uptake at lower [125I]AHIgG doses. Rats given cobr...Continue Reading

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Citations

Sep 15, 1982·Klinische Wochenschrift·R B SterzelM Kashgarian
Oct 12, 2012·Autoimmune Diseases·Scott E Wenderfer, Trisha Thacker
Nov 1, 1979·The Journal of Clinical Investigation·L RaijA Michael
May 27, 2008·Journal of the International Society of Sports Nutrition·Christopher Scott
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·H WehnerM Staudenmeir
Feb 1, 1988·Kidney International·J GrondJ D Elema
Apr 1, 1975·Kidney International·R L VernierS M Mauer
Feb 1, 1980·Kidney International·A F MichaelS M Mauer
Sep 1, 1988·Kidney International·W A Border
Jan 1, 1989·Kidney International·S M MauerD M Brown
Oct 1, 1985·Kidney International·R C MonteiroP Lesavre
Sep 1, 1990·Toxicology and Applied Pharmacology·R S JaenkeM E Cartwright
Mar 1, 1981·The American Journal of Medicine·S M MauerD M Brown
Jan 1, 1981·Australian and New Zealand Journal of Medicine·A F Michael
Dec 1, 1976·The Journal of Pathology·K J Thomson, D R Turner
Nov 1, 1993·The American Journal of Physiology·P C SinghalE Valderrama

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