The GLP-1 Receptor Agonist Exenatide Ameliorates Bone Composition and Tissue Material Properties in High Fat Fed Diabetic Mice

Frontiers in Endocrinology
Sity Aishah MansurGuillaume Mabilleau

Abstract

Type 2 diabetes mellitus (T2DM) has recently been recognized as a significant risk factor for bone fragility. Careful investigations of bone mechanical properties in human studies suggested possible alterations of bone composition, although this axis has poorly been investigated. The main aim of this study was to evaluate the impact of high fat diet-induced diabetes and therapy using the clinically approved GLP-1 receptor agonist, exenatide, on tissue bone mechanical properties and compositional parameters. Male mice had free access to high fat diet for 16 weeks to induce diabetes prior to commencement of the study. Exenatide was administered twice daily by i.p. injection at a dose of 25 nmol/kg for 52 days. Normal and high fat diet fed (HFD) mice injected with saline were used as controls. Bone mechanical properties was assessed at the organ level by 3-point bending and at the tissue level by nanoindentation. Bone microarchitecture was investigated by microcomputed tomography and bone composition was evaluated by Fourier transform infrared imaging. HFD mice exhibited profound alterations of bone mechanical properties at both the organ and tissue level. Collagen maturity as well as trabecular and cortical bone microarchitecture...Continue Reading

References

Apr 29, 1988·Biochemical and Biophysical Research Communications·M YamauchiG L Mechanic
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1986·Diabetologia·M NauckW Creutzfeldt
Jul 1, 1993·Bone·C H Turner, D B Burr
Apr 1, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J C Seidell
Mar 7, 2001·The Journal of Clinical Endocrinology and Metabolism·A V SchwartzUNKNOWN Study of Osteoporotic Features Research Group
May 9, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H Ou-YangR Mendelsohn
Jun 5, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elsa S StrotmeyerUNKNOWN Health ABC Study
Jun 29, 2006·The Journal of Clinical Endocrinology and Metabolism·Denise E BondsKaren L Margolis
Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Jun 19, 2007·American Journal of Epidemiology·Mohsen JanghorbaniFrank B Hu
Feb 23, 2010·Metabolism: Clinical and Experimental·Janina M PatschPeter Pietschmann
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L BouxseinRalph Müller
Aug 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wesley G BeamerLeah Rae Donahue
Feb 25, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D ChappardM Audran
Mar 5, 2011·The Journal of Endocrinology·Bernardo Nuche-BerenguerMaría L Villanueva-Peñacarrillo
Dec 2, 2011·Methods in Molecular Biology·Eleftherios P Paschalis
Jan 18, 2012·Nature Reviews. Endocrinology·Christine HamannLorenz C Hofbauer
Oct 2, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·William D LeslieJohn A Kanis
Feb 22, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xue MaXiaoxing Luo
Aug 6, 2013·The Journal of Endocrinology·Guillaume MabilleauDaniel Chappard
Aug 17, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MieczkowskaG Mabilleau
Apr 29, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Karl J JepsenMarjolein C H van der Meulen
Jun 26, 2015·Endocrine·Han-Xiao SunBei Tao
Jul 28, 2015·Bone·Joshua N Farr, Sundeep Khosla
Oct 22, 2016·European Journal of Endocrinology·Iana M de AraújoFrancisco J A de Paula
Oct 26, 2016·British Journal of Clinical Pharmacology·Johanna H M DriessenRonald M A Henry
Feb 6, 2017·Calcified Tissue International·Eric AguadoDaniel Chappard
Nov 3, 2017·Endocrine·Paola LucianiAlessandro Peri
Dec 6, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A L BoskeyA V Schwartz
Dec 7, 2017·Frontiers in Endocrinology·Marie PereiraChantal Chenu
Nov 1, 2015·Expert Review of Endocrinology & Metabolism·Guillaume MabilleauNigel Irwin

❮ Previous
Next ❯

Citations

Jan 15, 2021·Food & Function·Jie QiaoYuezhong Ren
Nov 27, 2019·Molecular Metabolism·T D MüllerM H Tschöp
May 1, 2021·International Journal of Molecular Sciences·Antonia DonatJohannes Keller
Jul 3, 2020·Molecular and Cellular Endocrinology·Yun LiHongyun Lu
Apr 7, 2021·British Journal of Pharmacology·Neil TandayNigel Irwin
Jun 8, 2021·Frontiers in Endocrinology·Ryan A LaffertyPeter R Flatt
Jun 22, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Keiu HeinlaVallo Volke
Jul 3, 2021·International Journal of Molecular Sciences·Hideki KitauraItaru Mizoguchi
Oct 17, 2020·Expert Review of Endocrinology & Metabolism·Guillaume Mabilleau, Béatrice Bouvard
Aug 24, 2021·Frontiers in Endocrinology·Aleksandra MieczkowskaGuillaume Mabilleau

❮ Previous
Next ❯

Methods Mentioned

BETA
Infrared Imaging

Software Mentioned

Systat
Bluehill
GraphPad
Matlab
Prism

Related Concepts

Related Feeds

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.