The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer

Cancer Cell
Michael A Moses, Len Neckers

Abstract

Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, lipid synthesis, mTOR activity, and neutralization of reactive oxygen species. In this issue of Cancer Cell, Jeon and colleagues identify chemotherapy-induced endoplasmic reticulum stress as a novel strategy to target glutamine dependence.

Citations

Aug 9, 2016·Pharmacology & Therapeutics·John P Harrelson, Michael W Lee
Aug 5, 2019·Current Cancer Drug Targets·Xinjie Lu
Aug 15, 2018·Frontiers in Immunology·Jie YinYulong Yin
Sep 21, 2018·Frontiers in Cell and Developmental Biology·Mariafrancesca ScaliseCesare Indiveri
Jul 29, 2017·Journal of Hematology & Oncology·Marcus Kwong Lam Fung, Godfrey Chi-Fung Chan
Nov 27, 2020·Frontiers in Cell and Developmental Biology·Geetha Venkateswaran, Shoukat Dedhar
May 29, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fernanda Costa Brandão BertiDanielle Malheiros

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