PMID: 8606627Mar 1, 1996Paper

The glucagonoma syndrome. Clinical and pathologic features in 21 patients

Medicine
R A WermersR V Lloyd

Abstract

The glucagonoma syndrome is a rare disorder characterized by weight loss, necrolytic migratory erythema (NME), diabetes, stomatitis, and diarrhea. We identified 21 patients with the glucagonoma syndrome evaluated at the Mayo Clinic from 1975 to 1991. Although NME and diabetes help identify patients with glucagonomas, other manifestations of malignant disease often lead to the diagnosis. If the diagnosis is made after the tumor is metastatic, the potential for cure is limited. The most common presenting symptoms of the glucagonoma syndrome were weight loss (71%), NME (67%), diabetes mellitus (38%), cheilosis or stomatitis (29%), and diarrhea (29%). Although only 8 of the 21 patients had diabetes at presentation, diabetes eventually developed in 16 patients, 75% of whom required insulin therapy. Symptoms other than NME or diabetes mellitus led to the diagnosis of an islet cell tumor in 7 patients. The combination of NME and diabetes mellitus led to a more rapid diagnosis (7 months) than either symptom alone (4 years). Ten patients had diabetes mellitus before the onset of NME. No patients had NME clearly preceding diabetes mellitus. Increased levels of secondary hormones, such as gastrin (4 patients), vasoactive intestinal peptid...Continue Reading

References

Jul 1, 1978·Human Pathology·L I Larsson
Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·Z T BloomgardenD Rabinowitz
Aug 1, 1979·Annals of Internal Medicine·J A NortonM F Brennan
Oct 1, 1976·Physiological Reviews·R H Unger, L Orci
Apr 29, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·C CapellaP Fontana
Jun 1, 1977·Archives of Dermatology·R S KahanA Neimanis
Jan 1, 1977·Journal of Surgical Oncology·A KessingerJ F Foley
Jan 1, 1979·International Journal of Dermatology·A E Lewis
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J E LiljenquistD Rabinowitz
Nov 1, 1979·The British Journal of Dermatology·J A DoyleR S Rogers
Aug 31, 1978·The New England Journal of Medicine·P Raskin, R H Unger
Feb 26, 1976·The New England Journal of Medicine·R S SherwinP Felig
Dec 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M BukowskiT R Fleming
Nov 11, 1992·Metabolism: Clinical and Experimental·S KleinR R Wolfe
Oct 1, 1992·Baillière's Clinical Endocrinology and Metabolism·K D Buchanan
Oct 1, 1990·Journal of Clinical Gastroenterology·A E AlsinaR T Schweizer
Nov 1, 1991·The British Journal of Dermatology·S BlackfordD L Roberts
Nov 1, 1991·Journal of the American Academy of Dermatology·M E ShepherdE B Smith
Oct 1, 1991·Scottish Medical Journal·J D QuinA C MacCuish
Jun 1, 1990·Current Problems in Surgery·E MozellT M O'Dorisio
Jan 15, 1991·Cancer·E CersosimoM F Brennan
Mar 1, 1991·Journal of the American Academy of Dermatology·S J HuntE Abell
Jan 1, 1985·Acta Medica Scandinavica·L Elsborg, A Glenthøj
Jun 26, 1986·The New England Journal of Medicine·G BodenO E Owen
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·K S Nair
Aug 1, 1987·Annals of Internal Medicine·L K KvolsR G Hahn
Apr 1, 1988·Pathology, Research and Practice·G Klöppel, P U Heitz
Jul 1, 1986·The American Journal of Surgical Pathology·S M KheirI Lee
Jan 1, 1987·Metabolism: Clinical and Experimental·E RothJ Funovics
May 29, 1987·The American Journal of Medicine·L K Kvols, M Buck
Nov 1, 1987·The British Journal of Surgery·G P CopelandL J Hipkin
Sep 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G C MoriartyL A Sternberger
Jan 19, 1974·Lancet·D W WilmoreR H Unger
Jul 6, 1974·Lancet·C N MallinsonB Cox
Mar 1, 1974·The British Journal of Dermatology·R D Sweet

❮ Previous
Next ❯

Citations

Jun 6, 2007·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·I StarkC A Sander
Jun 19, 2012·Abdominal Imaging·Aparna BalachandranChuslip Charnsangavej
Jan 29, 2011·Langenbeck's Archives of Surgery·Simon SchimmackIrvin M Modlin
Sep 27, 2006·Pituitary·Eva Tiensuu Janson
May 18, 2013·Journal of General Internal Medicine·Stephanie A C HalvorsonBrett Sheppard
Mar 14, 2009·Current Gastroenterology Reports·Karen Davies, Kevin C Conlon
Sep 16, 2003·Cancer Treatment Reviews·Matthew H Kulke
Dec 22, 1999·Clinical and Experimental Dermatology·J A AlkemadeP C van de Kerkhof
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Aug 24, 2011·Journal of Medical Case Reports·Pablo Granero CastroJuan J González González
Mar 4, 2010·Journal of Experimental & Clinical Cancer Research : CR·Marialuisa Appetecchia, Roberto Baldelli
May 30, 2008·Endocrine-related Cancer·Thorvardur R HalfdanarsonGloria M Petersen
May 27, 2010·Srpski arhiv za celokupno lekarstvo·Radoje ColovićStojan Latincić
Mar 16, 2007·Journal of Neurosurgery. Spine·Maher QweiderVeit Rohde
Dec 15, 2012·Chinese Journal of Cancer·Cynthia RoRun Yu
Mar 13, 2003·Southern Medical Journal·Anjana AggarwalDaniel J Brotman
Mar 17, 2016·Case Reports in Surgery·Ashraf Al-FaouriAdnan Zayadeen
Dec 2, 2015·Oncology Letters·Jishu WeiY I Miao
May 24, 2001·The American Journal of the Medical Sciences·M A Chastain
Feb 22, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Raquel Guerrero VázquezElena Navarro González
Dec 19, 2015·International Journal of Dermatology·Jia HuoJianwen Ren
Jan 20, 2005·Gastroentérologie Clinique Et Biologique·Nathalie Lévy-BohbotUNKNOWN Groupe des Tumeurs Endocrines
Nov 27, 2007·Molecular and Cellular Endocrinology·Simona Grozinsky-GlasbergMárta Korbonits
Oct 31, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H L O'Grady, K C Conlon
Aug 3, 2006·Surgical Oncology Clinics of North America·Antonia E Stephen, Richard A Hodin
Jul 31, 2013·International Journal of Surgery·Bunzo NakataKosei Hirakawa
Nov 28, 2015·Surgical Oncology Clinics of North America·Gustavo G Fernandez RanvierWilliam B Inabnet
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kathleen ClaesYves Vanrenterghem
Aug 25, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·J M Remes-TrocheR Orozco-Topete
Dec 25, 2003·International Journal of Dermatology·Ramon M PujolArnold L Schroeter
Jun 28, 2008·Clinical and Experimental Dermatology·B LuzarE Calonje
Feb 10, 2006·Journal of Cutaneous Pathology·Réka K KovácsLajos Kemény
Jan 3, 2013·Asia-Pacific Journal of Clinical Oncology·Manas K SahooChandra Sekhar Bal
Mar 26, 2016·Surgical Oncology Clinics of North America·Carinne W Anderson, Joseph J Bennett
May 15, 2010·International Journal of Dermatology·Inês LoboRui Carvalho
Jun 3, 2004·The Journal of Surgical Research·John C Mansour, Herbert Chen
Jul 11, 2006·Clinics in Dermatology·Serge A JabbourRonni Wolf
Jan 18, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A H G DaviesUNKNOWN EORTC Quality of Life Group
Dec 14, 2005·Gastroenterology·Stefan SchanzGerhard Fierlbeck
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·Kjell Oberg, Barbro Eriksson
Feb 19, 2015·Journal of Hepato-biliary-pancreatic Sciences·Simona Grozinsky-GlasbergDavid J Gross
Jun 19, 2010·Orvosi hetilap·Csaba HalászlakiPéter Lakatos

❮ Previous
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