The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.

Molecular Endocrinology
P SuarezE Hummler

Abstract

The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in vivo, we have used Cre/loxP technology to generate mice deficient for Tsc22d3-2. Male knockout mice were viable but surprisingly did not show any major deficiencies in immunological processes or inflammatory responses. Tsc22d3-2 knockout mice adapted to a sodium-deprived diet and to water deprivation conditions but developed a subtle deficiency in renal sodium and water handling. Moreover, the affected animals developed a mild metabolic phenotype evident by a reduction in weight from 6 months of age, mild hyperinsulinemia, and resistance to a high-fat diet. Tsc22d3-2-deficient males were infertile and exhibited severe testis dysplasia from postnatal d 10 onward with increases in apoptotic cells within seminiferous tubules, an increased number of Leydig cells, and significantly elevated FSH and testosterone levels. Thus, our analysis of the Tsc22d3-2-deficient mice demonstrated a previously uncharacterized function of glucocorticoid-induced leucine zipper protein in testis devel...Continue Reading

References

Jan 1, 1991·Advances in Experimental Medicine and Biology·A Steinberger
May 1, 1990·Journal of Endocrinological Investigation·J A VazquezM A Busturia
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·L BentonM P Hardy
Oct 1, 1994·Endocrine Reviews·J M Saez
Jun 3, 2000·Nature Genetics·C I RodríguezS M Dymecki
Jun 3, 2000·Annual Review of Immunology·J D AshwellM S Vacchio
Jun 9, 2001·The Journal of Biological Chemistry·P R Mittelstadt, J D Ashwell
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Edith HummlerFriedrich Beermann
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Olivier G MullerJean-Daniel Horisberger
May 30, 2003·Biology of Reproduction·Gerson RothschildPeter Besmer
Aug 21, 2003·The Kaohsiung Journal of Medical Sciences·Yu-Chiao YangShow-Jen Hong
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karel De GendtGuido Verhoeven
May 28, 2004·Human Molecular Genetics·Partha S SarkarSita Reddy
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Hélène PrigentDjillali Annane
Oct 6, 2005·Blood·Lorenza CannarileCarlo Riccardi
Oct 12, 2005·The Journal of Biological Chemistry·Rama SoundararajanDavid Pearce
Oct 20, 2006·Experimental Gerontology·Andrzej Bartke
May 12, 2007·The Journal of Clinical Investigation·Emira AyroldiCarlo Riccardi
Oct 25, 2007·The Journal of Biological Chemistry·Rama SoundararajanDavid Pearce
Nov 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Haifa HamdiGabriel Perlemuter
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu WangShijun J Zheng
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·Volker VallonJames Stockand
Feb 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Thierry RogerThierry Calandra
Jul 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Emira Ayroldi, Carlo Riccardi
Jan 14, 2010·PPAR Research·Bonnie L Blazer-Yost
Feb 23, 2010·Molecular and Cellular Endocrinology·Christopher R CederrothSerge Nef

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Citations

Apr 16, 2013·Pharmacology & Therapeutics·Ana L AlessandriMauro M Teixeira
Apr 12, 2014·Current Opinion in Pharmacology·Bernard C Rossier
Nov 12, 2015·The Journal of Obstetrics and Gynaecology Research·Makoto ChiharaTakayuki Enomoto
Mar 26, 2016·Genesis : the Journal of Genetics and Development·Frank KoentgenPeter Mombaerts
May 29, 2015·Biology of Reproduction·Mickaël Di-LuoffoJacques J Tremblay
Aug 22, 2018·Development·Hue M LaRobin M Hobbs
Mar 16, 2019·Physiological Genomics·Elizabeth A SwansonDavid H Ellison
Feb 26, 2016·Clinical Epigenetics·Daniella KlebanerYan V Sun
Feb 7, 2015·Médecine sciences : M/S·Aurélie PépinMarc Pallardy
Nov 2, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph CalmetteVéronique Godot
Oct 2, 2019·Frontiers in Immunology·Lisa M Sevilla, Paloma Pérez
Feb 20, 2020·Immunopharmacology and Immunotoxicology·Deepa K Ingawale, Satish K Mandlik
Jan 25, 2020·Experimental & Molecular Medicine·Laurence DumeigeLaetitia Martinerie
Oct 4, 2020·The Journal of Pharmacology and Experimental Therapeutics·Mahmood Mozaffari

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