PMID: 6112655May 1, 1981Paper

The glucoregulatory response to intravenous glucose infusion in normal man: roles of insulin and glucose

Metabolism: Clinical and Experimental
L SaccàB Ungaro

Abstract

In order to differentiate the roles of hyperinsulinemia and hyperglycemia per se in the homeostatic response to i.v. glucose administration, two groups of normal subjects were given either glucose alone (3.5 mg kg-1 min-1) or glucose (3 mg kg-1 min-1) in conjunction with somatostatin (500 microgram hr-1), insulin (0.15 mU kg-1 min-1) and glucagon (1 ng kg-1 min-1). Glucose kinetics were measured by the primed-constant infusion of 3-3H-glucose. During the infusion of glucose alone, plasma glucose stabilized at levels 45--50 mg/dl above the fasting values. Endogenous glucose output was markedly suppressed by 85%--90% while glucose uptake rose to values very close to the infusion rate of exogenous glucose. Glucose clearance remained unchanged. Plasma insulin rose to three-fourfold while plasma glucagon fell by 25%--30%. When glucose was infused with somatostatin, insulin, and glucagon, plasma insulin was maintained at levels 50% above baseline while glucagon remained at preinfusion levels. Under these conditions, the infusion of exogenous glucose resulted in a progressive increase of plasma glucose which did not stabilize until the end of the study period (190 mg/dl at 120 min). Endogenous glucose production was consistently suppr...Continue Reading

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R S SherwinP Felic
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R A DeFronzoP Felig
Jul 1, 1978·The Journal of Clinical Investigation·R A DeFronzoP Felig
Nov 1, 1978·The Journal of Clinical Endocrinology and Metabolism·L SaccaR S Sherwin
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·J E LiljenquistD Rabinowitz
Oct 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·P FeligP J Mulrow
May 1, 1974·The Journal of Clinical Investigation·R S SherwinR Andres
Aug 1, 1971·The Journal of Clinical Investigation·P Felig, J Wahren

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Citations

Jul 1, 1988·Acta diabetologica latina·R PrandoS Accoto
Oct 1, 1982·Annals of Surgery·P R BlackD W Wilmore
Feb 1, 1982·The Journal of Clinical Investigation·L SaccàR S Sherwin
Jul 1, 1991·The Journal of Clinical Investigation·S R MyersA D Cherrington
Oct 1, 1993·The Journal of Clinical Investigation·D E HertzS C Denne
Dec 1, 1982·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·H P SauerweinV Cejka
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Chang An ChuAlan D Cherrington

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