PMID: 9550452Apr 29, 1998Paper

The glucose/insulin system and vitamin C: implications in insulin-dependent diabetes mellitus

Journal of the American College of Nutrition
J J Cunningham

Abstract

The cellular uptake of vitamin C (ascorbic acid, ASC) is promoted by insulin and inhibited by hyperglycemia. If a rise in plasma ASC is uncoupled from insulin replacement in insulin-dependent diabetes mellitus (IDDM) then the degree of hyperglycemia could account for "tissue scurvy" in IDDM. Leukocyte ASC is lower in IDDMs compared with nondiabetics when vitamin C consumption is adequate and our data suggest that this is a variable component of the pathophysiology of IDDM. The complications of diabetes mellitus are believed to result from either the intracellular accumulation of sorbitol or the nonenzymatic glycoxidation of proteins or both. With respect to the abnormal cellular accumulation of sorbitol, vitamin C supplementation has been shown to be effective in several studies of adults with diabetes; the situation regarding the prevention of protein glycoxidations by supplementation is presently unclear. The roles of ASC as an aldose reductase inhibitor and a water soluble antioxidant in body fluids are potentially very important as adjuncts to tight glycemic control in the management of diabetes. Tissue saturation and maximal physiologic function in IDDM may require supplemental vitamin C intake.

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Citations

Jul 20, 2002·Journal of Diabetes and Its Complications·Diana M LeePhilip E Cornwell
Sep 1, 2001·Environmental Toxicology and Pharmacology·H R Griffiths, J Lunec
Feb 27, 1998·Journal of the American College of Nutrition·J J Cunningham
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Dec 7, 2005·British Journal of Pharmacology·Csaba Kónya, Péter Ferdinandy
Jun 8, 2014·Biochimica Et Biophysica Acta·Gábor BánhegyiAndrás Szarka
Jun 26, 2012·Biochimica Et Biophysica Acta·Juan DuGarry R Buettner
Apr 20, 2002·Arquivos de neuro-psiquiatria·Jacqueline Nelisis ZanoniMarcílio Hubner de Miranda Neto
Dec 8, 2006·Annals of the New York Academy of Sciences·Mariam Al-ShamsiErnest Adeghate
Oct 18, 2019·Antioxidants & Redox Signaling·Annekatrien BoelÉva Margittai
Jun 22, 2000·The Journal of Biological Chemistry·S C RumseyM Levine
May 19, 2021·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Oyebisi Mistura AzeezKhalid Talha Biobaku

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