The glucosinolate breakdown product indole-3-carbinol acts as an auxin antagonist in roots of Arabidopsis thaliana

The Plant Journal : for Cell and Molecular Biology
Ella KatzDaniel A Chamovitz

Abstract

The glucosinolate breakdown product indole-3-carbinol functions in cruciferous vegetables as a protective agent against foraging insects. While the toxic and deterrent effects of glucosinolate breakdown on herbivores and pathogens have been studied extensively, the secondary responses that are induced in the plant by indole-3-carbinol remain relatively uninvestigated. Here we examined the hypothesis that indole-3-carbinol plays a role in influencing plant growth and development by manipulating auxin signaling. We show that indole-3-carbinol rapidly and reversibly inhibits root elongation in a dose-dependent manner, and that this inhibition is accompanied by a loss of auxin activity in the root meristem. A direct interaction between indole-3-carbinol and the auxin perception machinery was suggested, as application of indole-3-carbinol rescues auxin-induced root phenotypes. In vitro and yeast-based protein interaction studies showed that indole-3-carbinol perturbs the auxin-dependent interaction of Transport Inhibitor Response (TIR1) with auxin/3-indoleacetic acid (Aux/IAAs) proteins, further supporting the possibility that indole-3-carbinol acts as an auxin antagonist. The results indicate that chemicals whose production is indu...Continue Reading

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Citations

Aug 8, 2015·Plant Signaling & Behavior·Ella KatzDaniel A Chamovitz
Feb 2, 2017·Annual Review of Plant Biology·Tobias Züst, Anurag A Agrawal
Jun 18, 2017·The Plant Journal : for Cell and Molecular Biology·Ella Katz, Daniel A Chamovitz
Nov 9, 2017·International Journal of Molecular Sciences·János UrbancsokRalph Kissen
Jan 10, 2018·Frontiers in Plant Science·Siva K Malka, Youfa Cheng
May 15, 2018·Frontiers in Plant Science·Daniel VikMeike Burow
Feb 21, 2019·Annual Review of Plant Biology·Matthias Erb, Philippe Reymond
Dec 12, 2019·Molecular Biology Reports·Amit Kumar SinghBrijesh Singh Yadav
Aug 27, 2019·Frontiers in Plant Science·Ryosuke Sugiyama, Masami Y Hirai
Jun 13, 2020·The Plant Journal : for Cell and Molecular Biology·Ameth N GarridoC Daniel Riggs
Dec 24, 2019·Frontiers in Plant Science·Verena JeschkeMeike Burow
Jun 16, 2018·F1000Research·Ella KatzDaniel A Chamovitz
Nov 1, 2020·The Plant Journal : for Cell and Molecular Biology·Alin FinkelshteinDaniel A Chamovitz
Jan 21, 2021·International Journal of Molecular Sciences·Peter S MillardMeike Burow
Jan 23, 2021·Trends in Plant Science·Jhon Venegas-MolinaAlain Goossens
Mar 18, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Daniela Quezada-MartinezAnnaliese S Mason
Apr 9, 2021·Nature·Ole Herud-SikimićGerd Jürgens
Mar 27, 2021·The Plant Journal : for Cell and Molecular Biology·Lennard van der WoudeMartijn van Zanten
Jun 18, 2021·Biological Reviews of the Cambridge Philosophical Society·Prasun KumarJintae Lee
Apr 4, 2020·Cell Chemical Biology·Chung Sub KimJason M Crawford
Jul 3, 2021·Genes·Hugo Gerardo Lazcano-RamírezNayelli Marsch-Martínez
May 18, 2021·The New Phytologist·Constantine GaragounisKalliope K Papadopoulou
Jun 20, 2020·Journal of Agricultural and Food Chemistry·Sarahani HarunZeti-Azura Mohamed-Hussein
Sep 24, 2021·Nature Chemical Biology·Jing-Ke WengNatalia Dudareva
Sep 13, 2021·The New Phytologist·Esteban AlfonsoPhilippe Reymond

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