PMID: 9423927Jan 10, 1998Paper

The glutamate receptor/NO/cyclic GMP pathway in the hippocampus of freely moving rats: modulation by cyclothiazide, interaction with GABA and the behavioural consequences

Neuropharmacology
E FedeleM Raiteri

Abstract

Monitoring of extracellular cGMP during intracerebral microdialysis in freely moving rats permits the study of the functional changes occurring in the glutamate receptor/nitric oxide (NO) synthase/guanylyl cyclase pathway and the relationship of these changes to animal behaviour. When infused into the rat hippocampus in Mg2+-free medium, cyclothiazide, a blocker of desensitization of the AMPA-preferring receptor, increased cGMP levels. The effect of cyclothiazide (300 microM) was abolished by the NO synthase inhibitor L-NARG (100 microM) or the soluble guanylyl cyclase inhibitor ODQ (100 microM). During cyclothiazide infusion the animals displayed a pre-convulsive behaviour characterized by frequent "wet dog shakes" (WDS). Neither L-NARG nor ODQ decreased the WDS episodes. Both cGMP and WDS responses elicited by cyclothiazide were prevented by blocking NMDA receptor function with the glutamate site antagonist CGS 19755 (100 microM), the channel antagonist MK-801 (30 microM) or Mg2+ ions (1 mM). The AMPA/kainate receptor antagonists DNQX (100 microM) and NBQX (100 microM) abolished the WDS episodes but could not inhibit the cyclothiazide-evoked cGMP response. DNQX or NBQX (but not MK-801) elevated, on their own, extracellular cG...Continue Reading

References

Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Sep 1, 1992·Neuroreport·G RondouinJ Bockaert
Jan 11, 1991·Pharmacology·M A OriowoR R Ruffolo
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Jan 1, 1990·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·P N LeighT W Stone
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M L Mayer, L Vyklicky
Oct 17, 1989·European Journal of Pharmacology·J GarthwaiteS Moncada
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Sep 1, 1988·European Journal of Pharmacology·J LehmannP L Wood
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E H WongL L Iversen
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 1, 1993·Neuropharmacology·E Southam, J Garthwaite
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·B WendlandR W Tsien
Jan 1, 1994·European Journal of Pharmacology·R L SharpJ P Burnett
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L DinermanS H Snyder
May 17, 1994·European Journal of Pharmacology·D Luo, S R Vincent
May 1, 1995·Psychopharmacology·L J HerbergI C Rose
May 1, 1993·The Journal of Comparative Neurology·J G ValtschanoffH H Schmidt
Aug 1, 1994·Neuropharmacology·A M MoudyS M Rothman
Feb 1, 1994·The European Journal of Neuroscience·J M Burgunder, P T Cheung

❮ Previous
Next ❯

Citations

Feb 26, 2003·European Journal of Pharmacology·Mark J Millan, Mauricette Brocco
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
May 13, 1999·Progress in Neurobiology·E Fedele, M Raiteri
Aug 4, 2010·Brain Research·Shuzhen KongYun Wang
Aug 18, 2004·Neurochemistry International·Jan de Vente
Mar 7, 2002·American Journal of Physiology. Renal Physiology·Norma VázquezGerardo Gamba
Aug 18, 2004·Neurochemistry International·Olimpia PepicelliErnesto Fedele

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.