PMID: 9423833Jan 10, 1998Paper

The glutamate-rich protein (GLURP) of Plasmodium falciparum is a target for antibody-dependent monocyte-mediated inhibition of parasite growth in vitro

Infection and Immunity
Michael TheisenP Druilhe

Abstract

Monocyte-dependent as well as direct inhibitory effects of antimalarial antibodies point toward antigens accessible at the time of merozoite release as targets for biologically active antibodies capable of mediating protection against Plasmodium falciparum. The glutamate-rich protein (GLURP), being an antigen associated with mature schizont-infected erythrocytes, was therefore the object of the present investigation, in which we analyzed whether anti-GLURP antibodies can either interfere directly with merozoite invasion or act indirectly by promoting a monocyte-dependent growth inhibition, antibody-dependent cellular inhibition. GLURP-specific human immunoglobulin G (IgG) antibodies, from pooled IgG of healthy Liberian adults who were clinically immune to malaria, were purified by affinity chromatography on columns containing R0 (N-terminal nonrepetitive region of GLURP) or R2 (C-terminal repetitive region of GLURP) recombinant protein or synthetic peptides as ligands. Analysis of the pattern of reactivity of highly purified anti-GLURP antibodies led to the definition of at least four B-cell epitopes. One epitope was specific for R0, two were specific for R2, and the fourth displayed cross-reactivity between R0 and R2. None of ...Continue Reading

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Citations

Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali JafarshadPierre L Druilhe
Apr 9, 2001·Infection and Immunity·A N HodderR F Anders
Jan 28, 2006·Parasite Immunology·K Marsh, S Kinyanjui
Feb 29, 2008·Tropical Medicine & International Health : TM & IH·I NebieB S Sirima
May 1, 2008·Expert Review of Vaccines·Rajeev K TyagiAbhinav Mehta
Dec 22, 2010·Malaria Journal·Roma Chilengi, Jesse Gitaka
May 22, 2013·Journal of Tropical Medicine·Sriwipa Chuangchaiya, Kristina E M Persson
Feb 3, 2016·FEMS Microbiology Reviews·James G BeesonJack S Richards
Jul 13, 2017·Expert Review of Vaccines·Michael TheisenSubhash Singh
Apr 30, 2013·The Journal of Infectious Diseases·Micha Phill Grønholm JepsenMichael Theisen
Jun 13, 2017·Expert Review of Vaccines·Edward H NtegeTakafumi Tsuboi
Oct 28, 2017·FEMS Microbiology Reviews·Heledd M DaviesAndrew R Osborne

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