The Glutamate System as a Crucial Regulator of CNS Toxicity and Survival of HIV Reservoirs.

Frontiers in Cellular and Infection Microbiology
Anna Maria Gorska, Eliseo A Eugenin

Abstract

Glutamate (Glu) is the most abundant excitatory neurotransmitter in the central nervous system (CNS). HIV-1 and viral proteins compromise glutamate synaptic transmission, resulting in poor cell-to-cell signaling and bystander toxicity. In this study, we identified that myeloid HIV-1-brain reservoirs survive in Glu and glutamine (Gln) as a major source of energy. Thus, we found a link between synaptic compromise, metabolomics of viral reservoirs, and viral persistence. In the current manuscript we will discuss all these interactions and the potential to achieve eradication and cure using this unique metabolic profile.

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Citations

Dec 6, 2020·Brain, Behavior, and Immunity·Lu DingJialin C Zheng
Feb 16, 2021·Cellular and Molecular Life Sciences : CMLS·Elena IrolloOlimpia Meucci
Apr 18, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Umit Haluk YesilkayaYasin Hasan Balcioglu
Oct 8, 2021·ASN Neuro·Chitra Mohinder Singh SingalPankaj Seth

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Methods Mentioned

BETA
nuclear translocation
NMR

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