The glutathione levels are reduced in Goto-Kakizaki rat retina, but are not influenced by aminoguanidine treatment

Current Eye Research
C D AgardhC G Ostenson

Abstract

To examine the levels of the free radical protecting enzyme glutathione and the endothelial/pericyte ratio in retinal capillaries in the Goto-Kakizaki (GK) Wistar rat, with and without aminoguanidine treatment. Eight-month-old GK rats, with non-obese, spontaneous non-insulin-dependent diabetes mellitus (NIDDM), were examined after a six month period of aminoguanidine treatment. Glutathione levels were measured with high performance liquid chromatography and the endothelial/pericyte ratio was calculated in trypsin digested vessel preparations. The levels of glutathione in GK rat retina were significantly lower compared to controls (p = 0.0108). There was no difference in the endothelial/pericyte ratio compared to matched control rats (1.8 +/- 0.2 vs. 1.8 +/- 0.1, respectively). Aminoguanidine treatment did not influence either the degree of hyperglycemia, the levels of glutathione or the endothelial/pericyte ratio in GK or control rat retina. The results indicate that impaired glucose metabolism may influence one of the defense mechanisms for oxidative stress, but also suggest that decreased glutathione levels occur prior to morphological signs of pericyte loss and/or endothelial cell proliferation in this animal model of heredi...Continue Reading

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Citations

Dec 17, 2005·Antioxidants & Redox Signaling·Carl-David AgardhElisabet Agardh
May 15, 2013·Journal of Diabetes Research·Xiao MiaoQuan Liu
Nov 16, 2004·Toxicology and Applied Pharmacology·Sohair A Moustafa
Nov 6, 2003·Redox Report : Communications in Free Radical Research·David M van ReykMichael J Davies
Dec 17, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Arthur Stevens
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shih-Chun YangShih-Yi Chuang
Mar 18, 2003·Diabetes Research and Clinical Practice·Kazuma MiwaNigishi Hotta

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