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The glycan domain of thrombopoietin enhances its secretion

Biochemistry

Mar 15, 2000

Hannah M Linden, Kenneth Kaushansky

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Abstract

Thrombopoietin (TPO) is the major regulator of megakaryocyte development and platelet production. The hormone is structurally characterized by an amino-terminal receptor binding domain (amino acid residues 1-152) predicted to encode a left-handed four-helix bundle structure, and a carbo...read more

Mentioned in this Paper

Asparagine
MFSD10 gene
Transfection
Molecular Helix
Murine
Mutagenesis, Site-Directed
Thrombopoiesis
Tertiary Protein Structure
Helix (Snails)
Chinese Hamster Ovary Cell
10
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The glycan domain of thrombopoietin enhances its secretion

Biochemistry

Mar 15, 2000

Hannah M Linden, Kenneth Kaushansky

PMID: 10715125

DOI: 10.1021/bi991756h

Abstract

Thrombopoietin (TPO) is the major regulator of megakaryocyte development and platelet production. The hormone is structurally characterized by an amino-terminal receptor binding domain (amino acid residues 1-152) predicted to encode a left-handed four-helix bundle structure, and a carbo...read more

Mentioned in this Paper

Asparagine
MFSD10 gene
Transfection
Molecular Helix
Murine
Mutagenesis, Site-Directed
Thrombopoiesis
Tertiary Protein Structure
Helix (Snails)
Chinese Hamster Ovary Cell
10

Feeds With Similar Papers

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

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Paper Details
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  • Citations21
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations21
123

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