The glycosaminoglycans of the gubernaculum during testicular descent in the fetus

The Journal of Urology
C F HeynsD P De Klerk

Abstract

Tissues were obtained from 387 male pig fetuses ranging from 60 to 120 days of gestation. The relative wet mass and water content of the gubernaculum increased during and decreased after the period of testicular descent. The extracellular glycosaminoglycans (GAG) were assayed to determine whether these polyanionic macromolecules are responsible for the increased water content of the gubernaculum. The total GAG/wet tissue mass in the gubernaculum decreased during and increased after descent, while the total GAG/dry mass decreased during and after descent, indicating an accumulation of water during descent, with a loss of water and an increase in less hydrated tissue components after descent. The major GAG fraction in the gubernaculum was dermatan sulfate, but the percentage hyaluronate in the gubernaculum was two times higher than in striated muscle or umbilical cord, indicating that this GAG fraction may be responsible for the increased water content of the gubernaculum, which probably serves to dilate the inguinal canal and scrotum, thus facilitating descent.

References

May 1, 1986·The Journal of Urology·C F HeynsD P De Klerk
Apr 1, 1985·The Journal of Urology·C F Heyns, D P de Klerk
Nov 1, 1969·The American Journal of Medicine·K Meyer
Jun 1, 1969·Biology of Reproduction·H T Gier, G B Marion
Mar 18, 1970·Biochimica Et Biophysica Acta·T Ohya, Y Kaneko
Jan 1, 1983·The Prostate·D P De Klerk
May 1, 1984·The Journal of Urology·D P De KlerkH J Human

❮ Previous
Next ❯

Citations

Jun 10, 2005·Biology of Reproduction·Christophe StaubBernard Jégou
Mar 16, 2011·Nature Reviews. Urology·Katrine BayNiels E Skakkebæk
Apr 8, 2016·The Veterinary Record·A ScolloC Mazzoni
Apr 1, 1997·Endocrine Reviews·J M HutsonC F Heyns
May 15, 2013·Endocrine Reviews·John M HutsonNan Chen
Jul 31, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Jan 24, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Luciano A FavoritoFrancisco J B Sampaio
May 12, 2004·Developmental Biology·Thomas KlonischSabine Hombach-Klonisch
Oct 25, 2008·Journal of Pediatric Urology·Hideki TomiyamaJohn M Hutson
Sep 19, 2007·Seminars in Ultrasound, CT, and MR·Jared D Christensen, Vikram S Dogra
Feb 5, 2011·Journal of Pediatric Surgery·Shobhana NagrajJohn M Hutson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.