The golden death bacillus Chryseobacterium nematophagum is a novel matrix digesting pathogen of nematodes

BMC Biology
Antony P PageWilliam Weir

Abstract

Nematodes represent important pathogens of humans and farmed animals and cause significant health and economic impacts. The control of nematodes is primarily carried out by applying a limited number of anthelmintic compounds, for which there is now widespread resistance being reported. There is a current unmet need to develop novel control measures including the identification and characterisation of natural pathogens of nematodes. Nematode killing bacilli were isolated from a rotten fruit in association with wild free-living nematodes. These bacteria belong to the Chryseobacterium genus (golden bacteria) and represent a new species named Chryseobacterium nematophagum. These bacilli are oxidase-positive, flexirubin-pigmented, gram-negative rods that exhibit gelatinase activity. Caenorhabditis elegans are attracted to and eat these bacteria. Within 3 h of ingestion, however, the bacilli have degraded the anterior pharyngeal chitinous lining and entered the body cavity, ultimately killing the host. Within 24 h, the internal contents of the worms are digested followed by the final digestion of the remaining cuticle over a 2-3-day period. These bacteria will also infect and kill bacterivorous free-living (L1-L3) stages of all teste...Continue Reading

References

Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Feb 7, 2001·Clinical Microbiology Reviews·S Geerts, B Gryseels
Dec 19, 2003·Nucleic Acids Research·Rolf ApweilerLai-Su L Yeh
Dec 19, 2003·Nucleic Acids Research·Alex BatemanSean R Eddy
Sep 15, 2004·Trends in Parasitology·Adrian J WolstenholmeNicholas C Sangster
Apr 4, 2006·Journal of Animal Science·M Larsen
Oct 31, 2006·The Veterinary Clinics of North America. Food Animal Practice·Bert E Stromberg, Louis C Gasbarre
Feb 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth PradelJonathan J Ewbank
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Creg Darby
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Antony P Page, Iain L Johnstone
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Susan E Mango
Mar 14, 2008·Nature·Ronald KaminskyPascal Mäser
Jun 20, 2008·The New Phytologist·Victoria L FullerPeter E Urwin
Aug 30, 2008·Current Opinion in Infectious Diseases·Alice Chijioke Eziefula, Michael Brown
Oct 23, 2008·Nucleic Acids Research·William KlimkeTatiana Tatusova
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jan 24, 2013·PloS One·Adrian M AltenhoffChristophe Dessimoz
Feb 22, 2013·The ISME Journal·Peter BurlinsonGail M Preston
May 7, 2013·Nature Methods·Chen-Shan ChinJonas Korlach
Mar 13, 2014·Expert Review of Vaccines·James P Hewitson, Rick M Maizels
Mar 20, 2014·Bioinformatics·Torsten Seemann
May 31, 2016·Advances in Parasitology·A C Kotze, R K Prichard

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Citations

Oct 12, 2020·Archives of Microbiology·Alazea M TamezJinSong Zheng
Mar 7, 2021·Science·D Dipon GhoshMichael N Nitabach
Mar 19, 2021·Microbiology and Molecular Biology Reviews : MMBR·Leah J Radeke, Michael A Herman
Sep 28, 2021·International Journal of Systematic and Evolutionary Microbiology·Teresa LucenaMaría J Pujalte
Jan 28, 2021·Phytopathology·Matthew A TancosElizabeth E Rogers

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Datasets Mentioned

BETA
PRJNA487926

Methods Mentioned

BETA
transgenic

Software Mentioned

HGAP
minimap2
Samtools
SMRTlink
Axiovision
Circlator
PROKKA
Quiver
SMRT
InterProScan

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Anthelmintics (ASM)

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