The Golgin Family of Coiled-Coil Tethering Proteins

Frontiers in Cell and Developmental Biology
Tomasz M Witkos, Martin Lowe

Abstract

The golgins are a family of predominantly coiled-coil proteins that are localized to the Golgi apparatus. Golgins are present in all eukaryotes, suggesting an evolutionary conserved function. Golgins are anchored to the Golgi membrane by their carboxy terminus and are predicted to adopt an extended conformation that projects into the surrounding cytoplasm. This arrangement is ideal for the capture or tethering of nearby membranes or cytoskeletal elements. Golgin-mediated tethering is thought to be important for vesicular traffic at the Golgi apparatus, the maintenance of Golgi architecture, as well as the positioning of the Golgi apparatus within cells. In addition to acting as tethers, some golgins can also sequester various factors at the Golgi membrane, allowing for the spatiotemporal regulation of downstream cellular functions. Although it is now established that golgins are membrane and cytoskeleton tethers, the mechanisms underlying tethering remain poorly defined. Moreover, the importance of golgin-mediated tethering in a physiological context remains to be fully explored. This review will describe our current understanding of golgin function, highlighting recent progress that has been made, and goes on to discuss outsta...Continue Reading

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Citations

Mar 26, 2016·Frontiers in Cell and Developmental Biology·Peter Fisher, Daniel Ungar
Dec 29, 2016·Proceedings of the National Academy of Sciences of the United States of America·Chunyi LiuShilai Bao
May 5, 2017·Journal of Cell Science·Chia-Jung Yu, Fang-Jen S Lee
Dec 24, 2017·Biochemical Society Transactions·Alison K Gillingham
Sep 27, 2019·Scientific Reports·Fatema B AlmughlliqMurray D Mitchell
Jul 19, 2019·Frontiers in Cell and Developmental Biology·Martin Lowe
Aug 10, 2019·Frontiers in Cell and Developmental Biology·Fabiola MascanzoniAntonino Colanzi
Apr 8, 2020·Frontiers in Cell and Developmental Biology·Yingfeng TuDa Jia
Mar 16, 2017·Protoplasma·Tomáš Mazel
Feb 6, 2020·Biochemical Society Transactions·Inmaculada AyalaAntonino Colanzi
Jun 12, 2019·Nature Ecology & Evolution·Jacob M DaaneMatthew P Harris
Jul 8, 2020·International Journal of Molecular Sciences·Peter T A LindersGeert van den Bogaart
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Sanae UedaJoji Mima
Jan 30, 2021·Frontiers in Cell and Developmental Biology·Aurora Gil-HernándezAlejandro Silva-Palacios
Jan 17, 2021·Applied and Environmental Microbiology·Chenyu WangHansong Dong
Jun 1, 2021·Frontiers in Cell and Developmental Biology·Xiaoyan Zhang
Aug 24, 2021·Frontiers in Molecular Neuroscience·Chad W Sauvola, J Troy Littleton
Nov 19, 2021·Progress in Lipid Research·Rebekah Rakotonirina-RicquebourgVitor Teixeira
Jan 1, 2022·Proceedings of the National Academy of Sciences of the United States of America·Giovanna GrimaldiDaniela Corda

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Datasets Mentioned

BETA
GM130
GM130-p115

Methods Mentioned

BETA
GTPases
GTPase
nucleotide exchange

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