The golli-myelin basic protein negatively regulates signal transduction in T lymphocytes

Journal of Neuroimmunology
Ji-Ming FengAnthony T Campagnoni

Abstract

Protein kinase C (PKC) plays a critical role in signal transduction controlling T lymphocyte activation. Both positive and negative regulation of signal transduction is needed for proper control of T lymphocyte activation. We have found that a golli product of the myelin basic protein (MBP) gene can serve as a negative regulator of signaling pathways in the T lymphocyte, particularly the PKC pathway. Increased expression of golli BG21 in Jurkat T cells strongly inhibits anti-CD3-induced IL-2-luciferase activity, an indicator of T lymphocyte activation. Golli BG21 can be phosphorylated by PKC in vitro and its phosphorylation increases in PMA-activated Jurkat cells. BG21 inhibits the PMA-induced increase in AP-1 or NF-kappaB activation, consistent with golli acting in a PKC-mediated cellular event. Golli BG21 inhibition of the PKC pathway is not due to a direct action on PKC activation but in the cascade following PKC activation, since BG21 neither reduces PKC enzyme activity nor blocks the membrane association of PKCtheta brought on by T lymphocyte activation. The inhibitory function of BG21 is independent of its phosphorylation by PKC because a mutant BG21, in which the PKC sites have been mutated, is as effective as the wild t...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·R MartinD E McFarlin
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T M PribylA T Campagnoni
Jun 1, 1995·Current Opinion in Immunology·J JainA Rao
Jun 1, 1994·Current Opinion in Immunology·B M Sefton, J A Taddie
Jan 1, 1994·Annual Review of Biochemistry·G R Crabtree, N A Clipstone
Oct 20, 1999·The Journal of Cell Biology·P W JanesA I Magee
Feb 9, 2000·The Journal of Experimental Medicine·T SosinowskiA Weiss
Mar 8, 2000·The Journal of Experimental Medicine·E S Huseby, J Goverman
Mar 21, 2000·Seminars in Immunology·P W JanesP S Kabouridis
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J M FengA T Campagnoni
Nov 30, 2000·Immunology Today·A AltmanG Baier
Apr 20, 2001·Seminars in Immunology·K Bi, A Altman

❮ Previous
Next ❯

Citations

Jun 9, 2012·Journal of Neuroinflammation·Huaqing LiuVeronica I Shubayev
Oct 5, 2007·Genome Biology·Ker-Chau LiLeena Peltonen
Apr 6, 2006·PLoS Genetics·Janna SaarelaLeena Peltonen
Feb 20, 2007·PLoS Pathogens·Jean-Pierre RoussarieMichel Brahic
Oct 20, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Vanessa Kiyomi OtaSintia Iole Belangero
Sep 30, 2008·European Journal of Oral Sciences·Hyun-Jin KimSun-Hun Kim
Jul 16, 2010·The Biochemical Journal·Ciara M WalshRobert D Burgoyne
Apr 18, 2015·Genome Biology·Charles F SpurlockThomas M Aune
Apr 23, 2014·Biochemical and Biophysical Research Communications·Sergio Jaramillo-TatisGeorge Harauz
Jan 22, 2009·The International Journal of Neuropsychopharmacology·Kuti BaruchRuth Navon
May 1, 2016·Biochimica Et Biophysica Acta·Jose J LopezJuan A Rosado
Mar 18, 2005·Journal of Neuroscience Research·L S DeBruinG Harauz
Feb 13, 2019·Molecular Biology Reports·Anddre Osmar ValdiviaSanjoy K Bhattacharya
Sep 27, 2019·Current Drug Targets·Sampath Bhuvaneshwari, Kavitha Sankaranarayanan
Sep 25, 2015·Physiological Reviews·Murali Prakriya, Richard S Lewis
Oct 26, 2016·Molecular Medicine Reports·Juanyong XuYuan Fan
Oct 7, 2006·Neurochemical Research·Ji-Ming Feng
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie J RamosCraig M Walsh
Jul 23, 2021·The Journal of Investigative Dermatology·Kuang-Den ChenHo-Chang Kuo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.