The GoMo study: a randomized clinical trial assessing neonatal pain with Gomco vs Mogen clamp circumcision

American Journal of Obstetrics and Gynecology
Rachel G SinkeyMounira A Habli

Abstract

Our objective was to compare the pain/stress levels of newborns among the 2 most common circumcision techniques after resident-wide education. The study period of this randomized control trial was October 2012 through March 2014. Following informed consent, full-term males from uncomplicated singleton pregnancies were randomized to Gomco (n=137) or Mogen (n=137) devices. Resident-wide education for an obstetrics and gynecology residency program at a single institution was performed to ensure standardized training. All infants received a subcutaneous ring block before the procedure and oral sucrose intraoperatively. The primary outcome was neonatal pain assessed physiologically by salivary cortisol levels (enzyme-linked immunosorbent assay) and clinically by a validated neonatal pain score (crying, requires increased oxygen administration, increased vital signs, expression, sleeplessness [CRIES]). Secondary outcomes were immediate complications, duration of procedure, and short-term outcomes as reported by mothers and pediatricians. A sample size of 274 (accounting for 20% loss of follow-up) was determined sufficient to detect a mean difference of 1.22 μg/dL in cortisol levels (Gomco, SD±3.34; Mogen, SD±0.81) with 80% power, P=....Continue Reading

References

Oct 1, 1984·Journal of Developmental and Behavioral Pediatrics : JDBP·S DixonP Bromberger
Jan 1, 1984·Journal of the American Academy of Child Psychiatry·M R GunnarS Malone
Dec 1, 1982·Early Human Development·R E MarshallS B Boxerman
Jan 1, 1981·Psychoneuroendocrinology·M R GunnarJ M Donhowe
Aug 1, 1997·Pediatrics·H J StangM R Gunnar
Jun 4, 1998·Obstetrics and Gynecology·S Hardwick-SmithM L Ritchey
Jan 4, 2001·American Journal of Preventive Medicine·S E Kellerman, J Herold
Apr 12, 2002·Journal of Perinatology : Official Journal of the California Perinatal Association·H William TaeuschElena Fuentes-Afflick
Nov 20, 2002·Ambulatory Pediatrics : the Official Journal of the Ambulatory Pediatric Association·Latha Chandran, Patricia Latorre
Jul 3, 2004·Pediatrics·Ruth E GrunauMichael F Whitfield
Oct 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·C McNairB Stevens
Nov 3, 2006·Pediatrics·Daniel G BattonCarol Wallman
Sep 14, 2011·Journal of Clinical Research in Pediatric Endocrinology·Selim KurtoğluŞeyma Memur
Jan 14, 2012·British Journal of Nursing : BJN·Lavinia Raeside
Aug 29, 2012·Pediatrics·UNKNOWN American Academy of Pediatrics Task Force on Circumcision
Jan 15, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebeca M PlankShahin Lockman
Jun 26, 2013·Hormone Research in Pædiatrics·Débora Macedo CabralCarlos Antonio Bruno da Silva

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Citations

Sep 29, 2018·Hospital Pediatrics·Andrea HerasLourdes Cohen
Nov 15, 2016·Frontiers in Neurology·Eran Elhaik
Aug 5, 2020·European Journal of Pediatrics·Serena RossiCarlo Valerio Bellieni

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