PMID: 6895206Jan 1, 1981Paper

The gonads of human true hermaphrodites

Human Genetics
W A van Niekerk, A E Retief

Abstract

Gonadal distribution in 409 cases of human true hermaphroditism is reviewed. An ovary was found on the left side of the body in 62.8% of the cases and the testis on the right side in 59.5%. The ovotestis is the most common gonad of the true hermaphrodite; amongst 806 gonads in 406 cases it was found in 44.3%. In this paper we give a detailed description of the morphology of ovotestis, testis and ovary in the true hermaphrodite. In addition we discuss the effects of fetal androgens and Müllerian inhibiting factor on the Wolffian and Müllerian ducts. Correlations between chromosomal complement and gonadal distribution are presented. True hermaphrodites with a 46,XX karyotype most commonly have an ovary on one side and an ovotestis on the other side; those with a Y-chromosome have a testis in 61% of cases. An analysis of the ratio of ovarian and testicular tissue within ovotestes showed a continuum from very little ovarian tissue to a small portion of testicular tissue. Each type of tissue was clearly demarcated. Hypotheses for gonadal induction in the true hermaphrodite should take cognizance of these facts. True hermaphrodites with a 46,XX chromosomal complement were characterized by a male phenotype in 54% of cases. This group ...Continue Reading

Citations

Apr 1, 1987·Cancer Genetics and Cytogenetics·M S Verp, J L Simpson
Feb 1, 1996·Trends in Ecology & Evolution·U Mittwoch
May 12, 2004·Journal of Theoretical Biology·Ursula Mittwoch
Nov 1, 1994·The Journal of Pediatrics·C G HadjiathanasiouR Rappaport
Dec 26, 2001·Archives of Medical Research·J C Zenteno-RuizJ P Méndez
Jan 16, 1999·Baillière's Clinical Endocrinology and Metabolism·G D Berkovitz, T Seeherunvong
Mar 21, 2000·Journal of Paediatrics and Child Health·A M WalkerC F Verge
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gian Franco ZannoniGiovanni Neri
Apr 1, 1996·International Journal of Andrology·C ManieriV Martina
Jun 1, 1996·The Journal of Obstetrics and Gynaecology Research·A M SadiM Kiyuna
May 5, 2011·British Journal of Sports Medicine·Kaye N BallantyneJ Anton Grootegoed
Jun 1, 1985·Journal of Medical Genetics·U Mittwoch
Apr 1, 1993·Postgraduate Medical Journal·T T Tan, B A Khalid
Apr 1, 1996·The British Journal of Radiology·M J AblettS T Elliott
Sep 21, 2004·American Journal of Medical Genetics. Part a·Karem NietoGloria Queipo
Sep 1, 2010·Surgical Pathology Clinics·Theonia K Boyd
May 11, 2010·Medical Hypotheses·M Kemal Irmak
Mar 24, 2009·Journal of Pediatric Surgery·Rinus Wiersma, P K Ramdial
Mar 17, 2007·Pathology·Stanley J Robboy, Francis Jaubert
May 21, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sherry Aw, Michael Levin
Jan 22, 2009·Annals of the New York Academy of Sciences·M RamsayT de Ravel
Jul 24, 2012·American Journal of Medical Genetics. Part a·So Youn ShinEul-Ju Seo
Jan 25, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Futoshi MatsuiMasahiro Nakayama
Mar 1, 1990·Urology·C F HeynsC J Deale
Oct 1, 1996·Journal of Pediatric Surgery·D J LimP S Stevens
Feb 1, 1984·Journal of Pediatric Surgery·C Nihoul-FékétéN Josso
Aug 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Jul 1, 1987·American Journal of Medical Genetics·C RosenbergT H Chu
Jul 1, 1988·Prenatal Diagnosis·A S FreibergJ Mann
Oct 25, 2008·Journal of Pediatric Urology·R P Meijer, A E Groeneveld
Sep 1, 1995·The Journal of Urology·T J YuH Y Chen
Oct 25, 2008·Journal of Pediatric Urology·David B Meir, John M Hutson
Jul 15, 2015·The Journal of Endocrinology·Ian S McLennan, Michael W Pankhurst
Mar 20, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kranti S KhadilkarNalini S Shah
Sep 26, 2000·Molecular Genetics and Metabolism·U Mittwoch
Dec 8, 2004·Mechanisms of Development·Michael Levin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.