The Gonyaulax clock at 50: translational control of circadian expression

Cold Spring Harbor Symposia on Quantitative Biology
J W Hastings

Abstract

The unicellular circadian clock of Gonyaulax polyedra (now renamed Lingulodinium polyedrum) has provided important insights concerning circadian rhythmicity. Many, perhaps most, of its key systems are circadian-controlled, ranging from bioluminescence and photosynthesis to motility, cell division, and the synthesis of many proteins, favoring the "master clock" concept. But different rhythms may have different free-running periods and different phase angles under different T cycles, observations not easily accommodated in a single oscillator model. Gonyaulax has a feature significantly different from that of other known systems, namely, that clock control of protein synthesis occurs at the translational level. With one mRNA, this involves a protein binding to a 22-nucleotide region in the 3'-untranslated region (3'UTR), but no similar regions have been found in other mRNAs. Pulses of protein synthesis inhibitors cause phase shifts, whereas inhibitors of protein phosphorylation administered chronically cause period changes. In Gonyaulax and other systems, low temperature results in arrhythmicity. A return to a permissive temperature results in a reinitiation of the rhythm, with the phase established by the time of increase, simil...Continue Reading

References

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Citations

Apr 27, 2013·Integrative and Comparative Biology·Adam M ReitzelOren Levy
Aug 5, 2010·Physiological Genomics·Siddharth SukumaranRichard R Almon
Jan 19, 2011·Journal of Cell Science·Shihoko KojimaCarla B Green
Feb 13, 2010·Annual Review of Physiology·David K WelshSteve A Kay
Feb 12, 2011·Plant, Cell & Environment·Tyler D B Mackenzie, David Morse
Jan 31, 2012·Plant Biology·E M Farré
Mar 25, 2015·Current Biology : CB·Anderson G OliveiraJay C Dunlap
Dec 17, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Larry J Kricka, Philip E Stanley
Nov 8, 2014·Biochemistry·Zeenat B Noordally, Andrew J Millar
Sep 13, 2008·Current Biology : CB·Michael H HastingsJohn S O'Neill
Feb 27, 2014·Marine Genomics·Paola OliveriAngela Falciatore
Sep 5, 2013·Microorganisms·Martha Valiadi, Debora Iglesias-Rodriguez
Nov 1, 2013·Microorganisms·Sougata Roy, David Morse
Nov 4, 2017·RNA Biology·Sarah Catherine MillsAlbrecht G von Arnim
Jul 8, 2017·Reports on Progress in Physics·Erich J Mueller
Mar 16, 2019·Biology·C Robertson McClung
Mar 25, 2017·Frontiers in Endocrinology·Florian AtgerFrédéric Gachon
Jan 11, 2020·Frontiers in Cellular and Infection Microbiology·Priscilla Carvalho CabralNicolas Cermakian
Apr 13, 2018·Microorganisms·Sougata RoyDavid Morse
Feb 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Sacha N CoeselE Virginia Armbrust

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