The good and bad effects of cysteine S-nitrosylation and tyrosine nitration upon insulin exocytosis: a balancing act.

Current Diabetes Reviews
Dean A Wiseman, Debbie C Thurmond

Abstract

As understanding of the mechanisms driving and regulating insulin secretion from pancreatic beta cells grows, there is increasing and compelling evidence that nitric oxide (•NO) and other closely-related reactive nitrogen species (RNS) play important roles in this exocytic process. •NO and associated RNS, in particular peroxynitrite, possess the capability to effect signals across both intracellular and extracellular compartments in rapid fashion, affording extraordinary signaling potential. It is well established that nitric oxide signals through activation of guanylate cyclase-mediated production of cyclic GMP. The intricate intracellular redox environment, however, lends credence to the possibility that •NO and peroxynitrite could interact with a wider variety of biological targets, with two leading mechanisms involving 1) Snitrosylation of cysteine, and 2) nitration of tyrosine residues comprised within a variety of proteins. Efforts aimed at delineating the specific roles of •NO and peroxynitrite in regulated insulin secretion indicate that a highly-complex and nuanced system exists, with evidence that •NO and peroxynitrite can contribute in both positive and negative regulatory ways in beta cells. Furthermore, the ultimat...Continue Reading

Citations

Oct 19, 2013·Diabetologia·Olga Kruszelnicka
Jan 24, 2014·Analytical and Bioanalytical Chemistry·Jingshan LuSeiji Ito
Nov 5, 2013·Antioxidants & Redox Signaling·Jin O-UchiShey-Shing Sheu
Feb 27, 2013·Chemical Reviews·Yaoyang ZhangJohn R Yates
Sep 19, 2014·Biochemical Society Transactions·Dimitrios KioumourtzoglouGwyn W Gould
Nov 29, 2013·Journal of Pharmacological Sciences·Yukiko Kurohane Kaneko, Tomohisa Ishikawa
Jan 14, 2018·Biochemical Pharmacology·Sevda GheibiAsghar Ghasemi
Apr 29, 2021·Plant Cell Reports·Noushina IqbalFrancisco J Corpas
Jun 3, 2021·International Journal of Molecular Sciences·Rizwana Begum Syed NabiByung-Wook Yun

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