The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk

The Journal of Clinical Endocrinology and Metabolism
Ravi RetnakaranBernard Zinman

Abstract

Both gestational diabetes mellitus (GDM) and gestational impaired glucose tolerance (GIGT) identify women at risk of future cardiovascular disease, although the mediators of this risk are unknown. Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum. Fasting lipids were measured in 482 women in pregnancy and at 3 months postpartum. Antepartum glucose challenge test (GCT) and oral glucose tolerance test (OGTT) defined four gestational glucose tolerance groups: GDM (n = 136), GIGT (n = 89), abnormal GCT with normal glucose tolerance (NGT) on OGTT (abnormal GCT NGT) (n = 170), and normal GCT with NGT on OGTT (normal GCT NGT) (n = 87). In pregnancy, there were no significant differences between the groups in total and low-density lipoprotein (LDL) cholesterol, triglycerides, total cholesterol to high-density lipoprotein (HDL) cholesterol ratio, apolipoprotein B (apoB), apolipoprotein A1 (apoA1), and apoB to apoA1 ratio. At 3 months postpartum, however, each of the following lipid parameters progressively increased from normal GCT NGT to abnormal GCT NGT to GIGT to GDM: total cholesterol (...Continue Reading

Citations

Apr 29, 2010·Current Diabetes Reports·Kelly J HuntJeffrey E Korte
Nov 1, 2011·Current Diabetes Reports·Shannon D SullivanRobert Ratner
Oct 3, 2013·Cardiovascular Diabetology·Jelena TodoricAlexandra Kautzky-Willer
Mar 9, 2013·Medicine and Science in Sports and Exercise·Véronique GingrasJulie Robitaille
Jul 3, 2013·Journal of Diabetes Research·Shireen BrewsterRavi Retnakaran
Dec 18, 2013·Women's Health·Jürgen HarreiterAlexandra Kautzky-Willer
Oct 19, 2012·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ä BartelsK O'Donoghue
Oct 17, 2015·International Journal of Molecular Sciences·Maria Carolina Gongora, Nanette K Wenger
Apr 9, 2016·Journal of Clinical Lipidology·Vivian Nunes Kern PessôaLenita Zajdenverg
Jan 15, 2014·Taiwanese Journal of Obstetrics & Gynecology·Panchalli WangYuan-Horng Yan
Oct 3, 2015·European Journal of Endocrinology·Baz BazJean-François Gautier
Mar 26, 2013·Journal of the American College of Cardiology·Shireen BrewsterJohn S Floras
Apr 11, 2017·Journal of Diabetes and Its Complications·Sumedha AryaRavi Retnakaran
Jun 7, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Harpreet S BajajRavi Retnakaran
Jan 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Simone KewRavi Retnakaran
Dec 19, 2018·The Journal of Clinical Endocrinology and Metabolism·Margareta D PisarskaErica T Wang
Sep 21, 2016·Scientific Reports·Haichen LvYunlong Xia
Dec 30, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margie H DavenportMichelle F Mottola
May 7, 2020·International Journal of Epidemiology·Elina KeikkalaMarja Vääräsmäki
Dec 14, 2016·International Journal of Endocrinology·S BurlinaA Lapolla
Sep 10, 2019·International Journal of Endocrinology and Metabolism·Mona Zamanian AzodiReza Mahmoud Robati
Dec 1, 2011·Obstetric Medicine·Änne Bartels, Keelin O'Donoghue
Apr 24, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Eyal SheinerMoshe Hod
Jul 30, 2019·BioMed Research International·Hayfaa A WahabiHanadi Bakhsh
Oct 28, 2020·Reviews in Endocrine & Metabolic Disorders·Maleesa M PathiranaPrabha H Andraweera
Mar 30, 2021·Circulation·Nisha I ParikhUNKNOWN American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.