The gramicidin A channel: energetics and structural characteristics of the progression of a sodium ion in the presence of water.

Journal of Biomolecular Structure & Dynamics
C Etchebest, A Pullman

Abstract

The distribution of water molecules in the Gramicidin A (GA) channel is determined by theoretical computations, and the role of this water on the energetics of the system upon progression of a sodium cation through the channel is investigated. In the absence of the ion, water molecules form a chain along the channel, hydrogen bonded to one another and to the L carbonyl oxygens, while others stay at the entrances of the channel, hydrogen-bonded to the free carbonyl oxygens of the L-Tryptophan residues. According to the definition adopted for the "inside" and the "outside" of the channel, it is found to contain at most 7 or 9 water molecules. When a hydrated sodium cation approaches and enters the channel, the structural properties corresponding to the minimized total energy of the system GA-water-Na+ indicate a reorganization, but not a destruction, of the chain of water molecules. The "energy profile" for the system GA-Na+-(22 waters) is analyzed in terms of its components and in comparison to the corresponding intrinsic profile computed earlier in vacuo. It appears that the presence of water does not unduely modify the pathway or the qualitative features of the energetics of the cation passage, except at the entrance, where th...Continue Reading

References

Feb 1, 1985·Journal of Biomolecular Structure & Dynamics·C Etchebest, A Pullman
Mar 1, 1985·Biophysical Journal·K S KimE Clementi
Feb 1, 1985·Journal of Biomolecular Structure & Dynamics·R Lavery, B Pullman
Aug 9, 1972·Biochimica Et Biophysica Acta·V B Myers, D A Haydon
Mar 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D W Urry
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D W UrryT L Trapane
Apr 21, 1983·Biochimica Et Biophysica Acta·E R Decker, D G Levitt
Sep 1, 1983·Biophysical Chemistry·F Heitz, C Gavach
Aug 1, 1984·Biophysical Journal·D H MackayA T Hagler

❮ Previous
Next ❯

Citations

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J Ramstein, R Lavery
Apr 1, 1988·Journal of Biomolecular Structure & Dynamics·C Etchebest, A Pullman
Nov 10, 2001·Annual Review of Biomedical Engineering·J M Nitsche
May 23, 2012·Journal of Neuroscience Methods·Liyo KaoIra Kurtz
Apr 1, 1988·American Heart Journal·J Wikman-CoffeltD T Mason
Nov 1, 1987·Quarterly Reviews of Biophysics·A Pullman
Mar 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W AuffermannJ Wikman-Coffelt
Sep 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·W AuffermannJ Wikman-Coffelt
Jan 1, 1988·Heart and Vessels·T A WattersJ Wikman-Coffelt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.