PMID: 36454Apr 1, 1979

The granulation of ternary mixtures containing lactose and boric acid with different starches

The Journal of Pharmacy and Pharmacology
K T Jaiyeoba, M S Spring

Abstract

Ternary mixtures of lactose, boric acid and starch have been granulated by massing and screening. The properties of the granules have been compared with those resulting from granulation of blends of lactose and boric acid without starch. Potato, maize and rice starches have been studied as the third component at concentrations similar to those employed in tablet formulations. The starches caused a reduction in both mean granule size and granule strength. The effect is dependent on the proportions of the excipients. Increasing the amount of binder solution used gave bigger, stronger granules but did not compensate for the effects produced by the starches.

References

Jun 1, 1976·The Journal of Pharmacy and Pharmacology·W O Opakunle, M S Spring
Aug 1, 1965·The Journal of Pharmacy and Pharmacology·E Shotton, N Harb
Dec 1, 1971·The Journal of Pharmacy and Pharmacology·D Ganderton, B M Hunter

Citations

Jun 22, 2001·Pharmaceutical Development and Technology·P HolmC Larsen
Nov 30, 2012·Journal of Plastic Surgery and Hand Surgery·Cemal FıratAhmet Hamdi Aytekin
Jan 1, 1980·The Journal of Pharmacy and Pharmacology·K T Jaiyeoba, M S Spring
Jan 1, 1981·The Journal of Pharmacy and Pharmacology·K T Jaiyeoba, M S Spring
Jun 1, 1980·The Journal of Pharmacy and Pharmacology·K T Jaiyeoba, M S Spring

Related Concepts

Boric Acids
Microencapsulation
Pharmaceutical Excipient
Anhydrous lactose
Particle Size
Keoflo

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