The great escape; the hallmarks of resistance to antiangiogenic therapy

Pharmacological Reviews
Judy R van BeijnumArjan W Griffioen

Abstract

The concept of antiangiogenic therapy in cancer treatment has led to the approval of different agents, most of them targeting the well known vascular endothelial growth factor pathway. Despite promising results in preclinical studies, the efficacy of antiangiogenic therapy in the clinical setting remains limited. Recently, awareness has emerged on resistance to antiangiogenic therapies. It has become apparent that the intricate complex interplay between tumors and stromal cells, including endothelial cells and associated mural cells, allows for escape mechanisms to arise that counteract the effects of these targeted therapeutics. Here, we review and discuss known and novel mechanisms that contribute to resistance against antiangiogenic therapy and provide an outlook to possible improvements in therapeutic approaches.

References

Sep 1, 1987·The Journal of Cell Biology·A Orlidge, P A D'Amore
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Aug 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D Shepro, N M Morel
Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Nov 24, 1999·The Journal of Clinical Investigation·A BourdeauM Letarte
Feb 19, 2000·Circulation Research·V DjonovP H Burri
Mar 7, 2000·The American Journal of Pathology·P Nangia-MakkerA Raz
Sep 27, 2000·Neoplasia : an International Journal for Oncology Research·J L RubensteinM A Shuman
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Apr 6, 2001·The American Journal of Pathology·A K SoodM J Hendrix
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N ReinmuthL M Ellis
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·M J HendrixR E Seftor
Aug 8, 2002·Journal of the National Cancer Institute·Suyun HuangIsaiah J Fidler
Nov 5, 2002·Nature Reviews. Cancer·Shahin RafiiBeate Heissig
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah E DuffShant Kumar
Jul 8, 2003·The Journal of Pathology·Olivier De Wever, Marc Mareel
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
Jul 6, 2004·Nature Medicine·Daniel J CeradiniGeoffrey C Gurtner
Sep 24, 2004·The EMBO Journal·Franck LebrinPeter ten Dijke
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William P J LeendersRobert de Waal
Oct 7, 2004·Journal of the National Cancer Institute·Daisy W J van der SchaftMary J C Hendrix
Nov 2, 2004·Nature Reviews. Cancer·Margareta M Mueller, Norbert E Fusenig
Nov 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer LeCouterNapoleone Ferrara
Nov 19, 2004·Cancer Research·Kyoko HidaMichael Klagsbrun
Nov 19, 2004·Nature·Neil A BhowmickHarold L Moses
Nov 24, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kristian Pietras, Douglas Hanahan
Oct 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuichi OhkiAkimichi Ohsaka
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettGregory Y Lauwers
Dec 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerBrian I Rini
Dec 17, 2005·Cancer Research·Daisy W J van der SchaftArjan W Griffioen
Jan 13, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christophe F ChantrainEtienne Marbaix

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Citations

Oct 31, 2015·Annual Review of Pharmacology and Toxicology·Michael M GottesmanJean-Pierre Gillet
May 9, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Elisabeth J M HuijbersArjan W Griffioen
Sep 30, 2015·Scientific Reports·Andrea WeissPatrycja Nowak-Sliwinska
Apr 12, 2016·Frontiers in Cell and Developmental Biology·Paul C McDonaldShoukat Dedhar
Apr 1, 2015·Angiogenesis·Andrea WeissPatrycja Nowak-Sliwinska
Jun 2, 2015·Oncogenesis·R N Gacche
Sep 9, 2016·International Journal of Molecular Sciences·Mauricio P PintoGareth I Owen
Nov 2, 2016·The Journal of Clinical Investigation·Anitha K ShenoyJianrong Lu
Oct 26, 2016·Biological Reviews of the Cambridge Philosophical Society·Judy R van BeijnumArjan W Griffioen
Apr 6, 2017·Angiogenesis·Robert H BerndsenPatrycja Nowak-Sliwinska
Mar 25, 2017·Expert Opinion on Therapeutic Targets·Piyush BugdeYan Li
Mar 28, 2017·SLAS Discovery·Daniela UnterleuthnerHelmut Dolznig
Jan 4, 2018·International Journal of Molecular Sciences·Henrik Nienhüser, Thomas Schmidt
Dec 30, 2017·International Journal of Molecular Sciences·Hisatsugu Goto, Yasuhiko Nishioka
Jan 7, 2018·Acta Neuropathologica·Fabio VerginelliRenato Mariani-Costantini
May 17, 2018·Angiogenesis·Patrycja Nowak-SliwinskaArjan W Griffioen
Aug 14, 2018·The Journal of Pathology·Victor Ljl ThijssenArjan W Griffioen
Oct 30, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Naomi B Haas, Robert G Uzzo
Feb 20, 2018·Molecular Cancer·Wagner Ricardo MontorFabiana Henriques Machado de Melo
Jan 18, 2018·Expert Review of Anticancer Therapy·Francesca BattaglinFotios Loupakis
Oct 20, 2019·Angiogenesis·Parvin AkbariJudy R van Beijnum
Nov 7, 2019·International Journal of Molecular Sciences·Tomas KoltaiStephan J Reshkin
Jan 16, 2020·International Journal of Molecular Sciences·Anubhab MukherjeeSudip Mukherjee
Feb 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paz de la TorreAna I Flores
May 23, 2020·British Journal of Cancer·Magdalena RauschPatrycja Nowak-Sliwinska
Nov 19, 2015·Frontiers in Pharmacology·Albin JeanneStéphane Dedieu
Jan 4, 2017·International Journal of Hematology·Rana Jahanban-EsfahlanNosratollah Zarghami
Jun 21, 2019·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Sep 29, 2019·World Journal of Gastrointestinal Oncology·Hsi-Lung Hsieh, Ming-Ming Tsai
Oct 12, 2019·Cancers·Nako MaishiKyoko Hida
Jan 19, 2020·International Journal of Molecular Sciences·Wafaa S RamadanAdel Elmoselhi
Dec 23, 2019·Angiogenesis·Elizabeth A Kuczynski, Andrew R Reynolds
Jul 21, 2015·Oncotarget·Yvette W J PaulisArjan W Griffioen
Nov 9, 2016·International Journal of Oncology·Ewa MajJoanna Wietrzyk

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