The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism

Diabetes
Stéphanie ChevalierJosé A Morais

Abstract

Obesity is associated with an increase in the fractional contribution of gluconeogenesis (GNG) to glucose production. We tested if this was related to the altered protein metabolism in obesity. GNG(PEP) (via phosphoenol pyruvate [PEP]) was measured after a 17-h fast using the deuterated water method and 2H nuclear magnetic resonance spectroscopy of plasma glucose. Whole-body 13C-leucine and 3H-glucose kinetics were measured in the postabsorptive state and during a hyperinsulinemic-euglycemic-isoaminoacidemic clamp in 19 (10 men and 9 women) lean and 16 (7 men and 9 women) obese nondiabetic subjects. Endogenous glucose production was not different between groups. Postabsorptive %GNG(PEP) and GNG(PEP) flux were higher in obese subjects, and glycogenolysis contributed less to glucose production than in lean subjects. GNG(PEP) flux correlated with all indexes of adiposity and with postabsorptive leucine rate of appearance (Ra) (protein catabolism). GNG(PEP) was negatively related to the clamp glucose rate of disposal (Rd) and to the protein anabolic response to hyperinsulinemia. In conclusion, the increased contribution of GNG to glucose production in obesity is linked to increased postabsorptive protein catabolism and insulin resi...Continue Reading

References

Nov 1, 1992·The American Journal of Clinical Nutrition·R F KushnerL Danford
Jan 1, 1969·Advances in Enzyme Regulation·P FeligG F Cahill
Jan 1, 1970·Advances in Enzyme Regulation·E MarlissG F Cahill
Jan 1, 1995·The Journal of Clinical Investigation·B R LandauS C Kalhan
Oct 10, 1997·The American Journal of Clinical Nutrition·J A MoraisE B Marliss
Apr 29, 1998·The Journal of Clinical Investigation·K F PetersenG I Shulman
Apr 16, 1998·European Journal of Endocrinology·M C MooreA D Cherrington
Feb 2, 1999·The Journal of Clinical Investigation·X ChenG Boden
Jan 29, 2000·The American Journal of Clinical Nutrition·S Leij-HalfwerkJ P Wilson
Dec 20, 2000·American Journal of Physiology. Endocrinology and Metabolism·G BodenT P Stein
Feb 1, 1974·The Journal of Clinical Investigation·P FeligT Brundin
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·J G JonesC R Malloy
Mar 7, 2002·The Biochemical Journal·Emile van Schaftingen, Isabelle Gerin
Jan 18, 2003·Analytical Biochemistry·Shawn C BurgessCraig R Malloy
Feb 26, 2004·American Journal of Physiology. Endocrinology and Metabolism·Rita BasuRobert A Rizza
Mar 12, 2004·Metabolism: Clinical and Experimental·Stéphanie ChevalierJosé A Morais
Apr 6, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Brian C WeisCraig R Malloy
Aug 5, 2004·The Journal of Clinical Endocrinology and Metabolism·Amalia GastaldelliRalph A DeFronzo
Jan 5, 2005·The Journal of Nutritional Biochemistry·T Peter SteinCharles E Wade

❮ Previous
Next ❯

Citations

Oct 11, 2011·Amino Acids·María M AdevaCristóbal Donapetry
Jul 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Varman T SamuelGerald I Shulman
Dec 8, 2009·Human Reproduction Update·Scott M NelsonLucilla Poston
Aug 2, 2007·Annual Review of Nutrition·Frédéric TremblayAndré Marette
Apr 12, 2012·Journal of Lipid Research·Santhosh SatapatiShawn C Burgess
Sep 14, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Mitsumasa KamauraOsamu Tochikubo
Jun 28, 2011·The Journal of Endocrinology·Salvatore P MangiaficoBarbara C Fam
May 30, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stéphanie Chevalier, Samaneh Farsijani
Sep 26, 2012·Nature Reviews. Endocrinology·Debbie A LawlorScott M Nelson
Dec 19, 2012·Metabolic Engineering·Scott B Crown, Maciek R Antoniewicz
Jan 11, 2007·Kidney International·A J O'Sullivan, J J Kelly
May 9, 2012·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ivan ViegasJohn G Jones
Jun 3, 2008·Néphrologie & thérapeutique·Philippe ChauveauMichel Aparicio
Jun 8, 2007·Diabetes & Metabolism·C M SenaJ G Jones
Jun 3, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Patricia M Nunes, John G Jones
Feb 10, 2009·European Journal of Clinical Investigation·D H van RaalteM Diamant
Aug 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T C DelgadoMatthew Merritt
Jun 19, 2008·Diabetes/metabolism Research and Reviews·Frank Q NuttallMary C Gannon
Dec 18, 2010·Obesity·Christos S Katsanos, Lawrence J Mandarino
May 2, 2015·Biochemical and Biophysical Research Communications·Greg M KowalskiClinton R Bruce
Dec 13, 2012·Food & Function·Leah ColesPaul Moughan
Jan 2, 2015·Amino Acids·Ying YangGuoyao Wu
Sep 28, 2006·Diabetes·Dominic N ReedsKevin E Yarasheski
Jun 22, 2016·The Journal of Endocrinology·Yolanda Diz-ChavesFederico Mallo
Apr 18, 2018·American Journal of Physiology. Endocrinology and Metabolism·Junlong WangBin Liang
Aug 13, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Melania GagginiAmalia Gastaldelli
May 28, 2019·Isotopes in Environmental and Health Studies·Arnaud De LucaRegis Hankard
Jul 25, 2019·Obesity·David Raubenheimer, Stephen J Simpson
Jul 6, 2014·Physiological Reports·Senthure JeganathanOlasunkanmi A J Adegoke
Sep 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Margarethe HoenigDarin E Olson
May 30, 2020·Nutrients·Kalliopi Anna PouliaMichalis V Karamouzis
Sep 24, 2020·American Journal of Physiology. Cell Physiology·Kai ZouJoseph A Houmard

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