The greater inflammatory pathway-high clinical potential by innovative predictive, preventive, and personalized medical approach.

The EPMA Journal
Maria Giovanna MaturoChristine Nardini

Abstract

Impaired wound healing (WH) and chronic inflammation are hallmarks of non-communicable diseases (NCDs). However, despite WH being a recognized player in NCDs, mainstream therapies focus on (un)targeted damping of the inflammatory response, leaving WH largely unaddressed, owing to three main factors. The first is the complexity of the pathway that links inflammation and wound healing; the second is the dual nature, local and systemic, of WH; and the third is the limited acknowledgement of genetic and contingent causes that disrupt physiologic progression of WH. Here, in the frame of Predictive, Preventive, and Personalized Medicine (PPPM), we integrate and revisit current literature to offer a novel systemic view on the cues that can impact on the fate (acute or chronic inflammation) of WH, beyond the compartmentalization of medical disciplines and with the support of advanced computational biology. This shall open to a broader understanding of the causes for WH going awry, offering new operational criteria for patients' stratification (prediction and personalization). While this may also offer improved options for targeted prevention, we will envisage new therapeutic strategies to reboot and/or boost WH, to enable its progressi...Continue Reading

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Citations

May 28, 2020·International Journal of Molecular Sciences·Deyanira ContarteseMilena Fini
Feb 21, 2021·Biophysical Journal·A Sofia F OliveiraAdrian J Mulholland
May 1, 2021·Journal of Clinical Medicine·Łukasz GutowskiDorota Formanowicz

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Methods Mentioned

BETA
Rosetta Stone
dissection

Software Mentioned

CellDesigner
PPPM
PredictImmune

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